This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SIB is a condition occurring in human and nonhuman primate populations. Previous studies demonstrated an association between SIB and both stress and sleep disturbances. This study investigated these associations in rhesus monkeys before and after a planned move to a new building. They were videotaped from 9 pm to 3 am, before and after relocation. Eight saliva samples were collected per animal from 16 of the subjects, four during the week prior to, and four during the week following, the move. Overall activity and behaviors (abnormal, locomotion, scratch, self-groom, sleep, visual explore, other) were scored from the videotapes via 1-minute scan sampling. Locomotion increased and sleep decreased from pre- to post-move (P less than 0.05), and there was a significant interaction; sleep decreased in SIB, but not non-SIB, subjects (P less than 0.01). Salivary cortisol was higher after the move (P less than 0.001), but there was no SIB effect. There was a positive correlation between change in cortisol and change in activity from pre- to post-move (P less than 0.05).
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