Contrast enhancement is extensively used in clinical radiology, although the development of contrast material for use in ultrasound has been limited, and no completely satisfactory material is currently available. The ideal ultrasound contrast agent must be safe and highly echogenic, with no evidence of hemodynamic toxicity. Studies were performed to determine the safety and efficacy of a novel fluorocarbon emulsion (qw3600) which has been shown to produce dense myocardial enhancement in dogs. Five groups of two monkeys were imaged following 3 consecutive intravenous injections at five differing dosages. Clinical, hematologic, and hemodynamic parameters were monitored prior to, during, and at 1, 2, and 7 days post-treatment. Results of these studies have shown no significant changes in heart rate, electrocardiograms, or blood pressure (bp) at the lower doses studied. Higher doses resulted in transient reductions in bp which normalized within 30 sec, and transient elevations in lactic dehydrogenase (LDH) and serum glutamic-oxaloacetic transaminase (SGOT) which returned to baseline levels roughly 7 days post-dosing. Overall, no significant hemodynamic effects or cardiovascular toxicity was noted following 3 consecutive administrations at dosages sufficient to consistently produce dense myocardial opacification. Emulsion consistently produced saturable, dose-related enhancement of blood pool and myocardium in monkeys with peak myocardial enhancement at the mid-dose studied.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
2P51RR000169-34
Application #
3742061
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
34
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of California Davis
Department
Type
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618
Comrie, Alison E; Gray, Daniel T; Smith, Anne C et al. (2018) Different macaque models of cognitive aging exhibit task-dependent behavioral disparities. Behav Brain Res 344:110-119
Day, George Q; Ng, Jillian; Oldt, Robert F et al. (2018) DNA-based Determination of Ancestry in Cynomolgus Macaques (Macaca fascicularis). J Am Assoc Lab Anim Sci 57:432-442
Carroll, Timothy D; Jegaskanda, Sinthujan; Matzinger, Shannon R et al. (2018) A Lipid/DNA Adjuvant-Inactivated Influenza Virus Vaccine Protects Rhesus Macaques From Uncontrolled Virus Replication After Heterosubtypic Influenza A Virus Challenge. J Infect Dis 218:856-867
Midic, Uros; VandeVoort, Catherine A; Latham, Keith E (2018) Determination of single embryo sex in Macaca mulatta and Mus musculus RNA-Seq transcriptome profiles. Physiol Genomics 50:628-635
Almodovar, Sharilyn; Swanson, Jessica; Giavedoni, Luis D et al. (2018) Lung Vascular Remodeling, Cardiac Hypertrophy, and Inflammatory Cytokines in SHIVnef-Infected Macaques. Viral Immunol 31:206-222
Ciupe, Stanca M; Miller, Christopher J; Forde, Jonathan E (2018) A Bistable Switch in Virus Dynamics Can Explain the Differences in Disease Outcome Following SIV Infections in Rhesus Macaques. Front Microbiol 9:1216
Feng, Jun-Feng; Liu, Jing; Zhang, Lei et al. (2017) Electrical Guidance of Human Stem Cells in the Rat Brain. Stem Cell Reports 9:177-189
Han, Pengcheng; Nielsen, Megan; Song, Melissa et al. (2017) The Impact of Aging on Brain Pituitary Adenylate Cyclase Activating Polypeptide, Pathology and Cognition in Mice and Rhesus Macaques. Front Aging Neurosci 9:180
Pittet, Florent; Johnson, Crystal; Hinde, Katie (2017) Age at reproductive debut: Developmental predictors and consequences for lactation, infant mass, and subsequent reproduction in rhesus macaques (Macaca mulatta). Am J Phys Anthropol 164:457-476
Kyle, Colin T; Stokes, Jared; Bennett, Jeffrey et al. (2017) Cytoarchitectonically-driven MRI atlas of nonhuman primate hippocampus: Preservation of subfield volumes in aging. Hippocampus :

Showing the most recent 10 out of 408 publications