This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Several studies have shown that HIV infection is associated with a severe form of pulmonary hypertension that is indistinguishable from idiopathic arterial pulmonary hypertension. Although HIV-related pulmonary hypertension is not common, the incidence rate is many times higher than in the general population (1/4,000 vs. 2/1 million). The cellular and molecular mechanisms that account for pulmonary hypertension in HIV-infected patients remain undefined. Because non-human primate models of AIDS exhibit several organ-specific pathologies and recapitulate the immune deficiencies observed in patients, the study of SIV (and SHIV) infected rhesus macaques provides a suitable approach to analyze the mechanistic aspects of HIV-associated pulmonary hypertension.
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