This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: There is a complex interplay between virus and the host immune response following infection. This interaction is mediated largely through the expression of host chemokines and cytokines. In order to understand how a virus subverts the immune system, it is therefore necessary to first understand the signaling pathways that are disrupted following both acute and chronic viral infections. Simultaneous measurement of multiple immune response elements following virus exposure will lead to a better understanding of viral pathogenesis. The recent development of multiplex technology has opened an exceptional venue for the description of 'signature' cytokine/chemokine profiles. Our long-term goals are to utilize multiplex technology to establish normal immune response profiles in the rhesus macaque and subsequently to elucidate cytokine profile 'signatures' for viral pathogens. Biomolecular profiles established for normal primates will form the basis for a wide variety of subsequent studies. By establishing a baseline profile, it will be possible to determine which cytokines and chemokines are regulated in response to various stimuli, viral infection being just one such stimulus. This knowledge will enable us to target potential intervention strategies, as well as to shed light on the common versus unique elements of the host immune response to viral pathogens.
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