This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Objective: The objectives of these studies are to characterize and quantify nonviral gene delivery of nucleic acids complexed with cationic lipids to the central nervous system (CNS), including the extent of expression of candidate neuroprotective genes. These studies will lead to the development of DNA and mRNA as gene medicines for transient expression in a variety of clinical applications, such as pre-operatively to protect the brain. As a first step towards clinical use, it is essential to ensure that the nonviral delivery techniques are well-tolerated. It is equally important to examine the duration and intensity of expression, and to determine what other tissues, if any, demonstrate expression after delivery to the cerebrospinal fluid in the CNS.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000169-46
Application #
7562165
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
2007-05-01
Project End
2008-04-30
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
46
Fiscal Year
2007
Total Cost
$24,607
Indirect Cost
Name
University of California Davis
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
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