Abstract

FDA approved pharmacotherapy options for alcohol use disorders remain limited, with only three currently approved compounds (disulfiram, naltrexone and acamprosate). Recent studies highlight the potential for medications used for the treatment of other indications to be examined for the treatment of alcohol use disorders. Study of additional agents, particularly those that act through novel mechanisms, is needed to expand the range of pharmacotherapy options for alcohol use problems. Extensive preclinical studies indicate that neuroactive steroids medicate important effects of alcohol and support the examination of neuroactive steroid modulators as treatment options for alcohol use problems. Dutasteride, a widely prescribed medication for benign prostatic hypertrophy, bloci

Public Health Relevance

Heavy drinking remains a significant public health problem. Although several medications have been shown to help patients stop or reduce drinking, additional medication options are needed as there is considerable variablitity in effectiveness or tolerability of existing medications for individual patients. This study will examine a medication approved for other conditions for its potential use to help men reduce or stop drinking.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA003510-37
Application #
8601002
Study Section
Special Emphasis Panel (ZAA1-GG)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
37
Fiscal Year
2014
Total Cost
$256,392
Indirect Cost
$89,903

  Institution

Name
University of Connecticut
Department
Type
DUNS #
022254226
City
Farmington
State
CT
Country
United States
Zip Code
06030

  Publications

Weiss, Nicole H; Bold, Krysten W; Contractor, Ateka A et al. (2018) Trauma exposure and heavy drinking and drug use among college students: Identifying the roles of negative and positive affect lability in a daily diary study. Addict Behav 79:131-137
Armeli, Stephen; Covault, Jonathan; Tennen, Howard (2018) Long-term changes in the effects of episode-specific drinking to cope motivation on daily well-being. Psychol Addict Behav 32:715-726
Higgins-Biddle, John C; Babor, Thomas F (2018) A review of the Alcohol Use Disorders Identification Test (AUDIT), AUDIT-C, and USAUDIT for screening in the United States: Past issues and future directions. Am J Drug Alcohol Abuse 44:578-586
Petry, Nancy M; Zajac, Kristyn; Ginley, Meredith K (2018) Behavioral Addictions as Mental Disorders: To Be or Not To Be? Annu Rev Clin Psychol 14:399-423
Lieberman, Richard; Kranzler, Henry R; Levine, Eric S et al. (2018) Examining the effects of alcohol on GABAA receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells. Alcohol 66:45-53
Bauer, Lance O (2018) Inter-trial variability in brain activity as an indicator of synergistic effects of HIV-1 and drug abuse. Drug Alcohol Depend 191:300-308
Rash, Carla J; Petry, Nancy M; Alessi, Sheila M (2018) A randomized trial of contingency management for smoking cessation in the homeless. Psychol Addict Behav 32:141-148
Bauer, Lance O (2018) HIV/AIDS and an overweight body mass are associated with excessive intra-individual variability in response preparation. J Neurovirol 24:577-586
Petry, Nancy M; Alessi, Sheila M; Rash, Carla J et al. (2018) A randomized trial of contingency management reinforcing attendance at treatment: Do duration and timing of reinforcement matter? J Consult Clin Psychol 86:799-809
Rash, Carla J; Stitzer, Maxine; Weinstock, Jeremiah (2017) Contingency Management: New Directions and Remaining Challenges for An Evidence-Based Intervention. J Subst Abuse Treat 72:10-18

Showing the most recent 10 out of 238 publications