This component of the IARC competing renewal application qualifies the IARC for potential designation and funding as a Comprehensive Center (P60). The overall objective of the component is to advance alcohol research and its dissemination for the purpose of improving the treatment of alcohol-affected individuals and the prevention of alcohol-related problems. This will be accomplished through: (a) collaborative research partnerships with other institutions, especially minority and minority-serving institutions; (b) sponsoring and organizing the biennial scientific conference for pre- and post-doctoral fellows and young investigators; (c) continuing education opportunities to treatment professionals in clinical settings and to the community at large, especially those in the judiciary, administrative and legislative branches of State government; (d) the clinical teaching of the diagnosis and treatment of alcohol and drug abuse and dependence for (3rd year) medical students, and extension of the educational base to masters degree level students in the IU School of Social Work; (e) the Bench to Bench Program of Science Education in Alcohol Problems for Indiana Judges. These activities will draw upon the expertise of the IARC-affiliated faculty at Indiana and Purdue Universities that reflect the broadly-based research theme of the center's research programs: a) The genetic determinants of alcohol ingestive behavior and other responses to alcohol, b) The interplay of genetic, behavioral and social risk factors in the etiology of alcoholism, c) The neurobiological basis of alcohol addiction as manifested by craving, loss of control drinking, and relapse, which will serve as the basis for rational pharmacotherapeutic interventions, d) The intimate interaction of the pharmacokinetics of alcohol with its pharmacodynamic actions and how individual variability in both these domains influence susceptibility to problem and dependent drinking.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
2P60AA007611-16
Application #
6739301
Study Section
Special Emphasis Panel (ZAA1-AA (04))
Project Start
2002-01-01
Project End
2007-11-30
Budget Start
Budget End
2003-11-30
Support Year
16
Fiscal Year
2003
Total Cost
$195,221
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Weafer, Jessica; Ross, Thomas J; O'Connor, Sean et al. (2018) Striatal activity correlates with stimulant-like effects of alcohol in healthy volunteers. Neuropsychopharmacology 43:2532-2538
Weera, Marcus M; Fields, Molly A; Tapp, Danielle N et al. (2018) Effects of Nicotine on Alcohol Drinking in Female Mice Selectively Bred for High or Low Alcohol Preference. Alcohol Clin Exp Res 42:432-443
Gerke, Steven P; Agley, Jon D; Wilson, Cynthia et al. (2018) An Initial Assessment of the Utility of Validated Alcohol and Drug Screening Tools in Predicting 30-Day Readmission to Adult General Medicine Wards. Am J Med Qual 33:397-404
Bujarski, Spencer; Jentsch, J David; Roche, Daniel J O et al. (2018) Differences in the subjective and motivational properties of alcohol across alcohol use severity: application of a novel translational human laboratory paradigm. Neuropsychopharmacology 43:1891-1899
Plawecki, Martin Henry; White, Kurt; Kosobud, Ann E K et al. (2018) Sex Differences in Motivation to Self-Administer Alcohol After 2 Weeks of Abstinence in Young-Adult Heavy Drinkers. Alcohol Clin Exp Res 42:1897-1908
Plawecki, Martin H; Windisch, Kyle A; Wetherill, Leah et al. (2018) Alcohol affects the P3 component of an adaptive stop signal task ERP. Alcohol 70:1-10
Houck, Christa A; Grahame, Nicholas J (2018) Acute drug effects on habitual and non-habitual responding in crossed high alcohol preferring mice. Psychopharmacology (Berl) 235:2167-2175
Kareken, David A (2018) Missing motoric manipulations: rethinking the imaging of the ventral striatum and dopamine in human reward. Brain Imaging Behav :
Czachowski, Cristine L; Froehlich, Janice C; DeLory, Michael (2018) The Effects of Long-Term Varenicline Administration on Ethanol and Sucrose Seeking and Self-Administration in Male P Rats. Alcohol Clin Exp Res 42:453-460
Spence, John Paul; Reiter, Jill L; Qiu, Bin et al. (2018) Estrogen-Dependent Upregulation of Adcyap1r1 Expression in Nucleus Accumbens Is Associated With Genetic Predisposition of Sex-Specific QTL for Alcohol Consumption on Rat Chromosome 4. Front Genet 9:513

Showing the most recent 10 out of 308 publications