The Administrative Core (AC001) performs the centralized administrative functions for all 4 Research Projects (P001-P004) and coordinates the activities of the Resource Cores (C001 and C002) and the Information Dissemination Core (CD001). All components address the Overall Center Theme: Role of the Tetrapartite Synapse in Risk for and Response to Alcohol Drinking. Scientific advice and feedback are provided by the Program Advisory Committee (PAC), and executive decisions regarding Portland Alcohol Research Center (PARC) activities are made by the Steering Committee. The Steering Committee sets and continuously evaluates progress toward general scientific research directions and oversees quality control mechanisms in all areas of Center activity. For example, the Steering Committee played a significant role in synthesizing Center research results in the development of our current hypotheses regarding the extracellular matrix (ECM) and its role in circuit function underlying drinking behavior. Additionally, they identified synergies between continuing and new projects. The PAC evaluated our findings at a convened local meeting and provided advice with regard to proposed research. Newly appointed PAC members assisted in the review of written PARC components of the current competing application. AC001 will oversee genomics, bioinformatics and data sharing, biostatistical analyses, and training and educational enrichment and outreach activities. It will coordinate discussions among Core/Project PIs to facilitate hypotheses and data sharing, and direction changes if needed, based on cumulative data. There are two lines of administrative responsibility within AC001. The general administrative coordination of all Center activities and the Center's budget will be supervised by Dr. Richards, the Center Director. The coordination of and future planning for scientific directions will be supervised by Dr. Grant, the Scientific Director, with input from Dr. Richards, the rest of the Steering Committee and PAC. Dr. Grant will act as Director in Dr. Richards' absence. Drs. Richards and Grant have worked together on the Center for the past 10 years and formed a productive alliance in the development of the current application.
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