Abstract

To adequately address a clinical research hypothesis requires a combination of clinical expertise, a good study design and appropriate outcomes and analytic methods. The goals of the Evaluation and Biostatistics Core are to provide methodological and statistical support to the Harvard OAIC clinical researchers in order to conduct and develop well-designed studies related to the independence of older persons.
Specific Aims of the core include methodological and statistical support, clinical intervention development support, development of novel outcomes for variable clinical conditions, and exploration of analytic methods for correlated data.
These aims will be achieved through regular interactions with the IDS and pilot project investigators, meetings with junior investigators for the development of new pilot projects and IDS investigators for the development of new clinical interventions, and participation in monthly Clinical Research Seminars. The core will also develop new methodology for the identification of distinct outcome trajectories and explore analytic methods for the analysis of correlated data arising from the IDS and pilot projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Comprehensive Center (P60)
Project #
2P60AG008812-11A1
Application #
6550875
Study Section
Special Emphasis Panel (ZAG1)
Project Start
1990-03-01
Project End
2006-06-30
Budget Start
Budget End
Support Year
11
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Foley, Jessica M; Salat, David H; Stricker, Nikki H et al. (2016) Glucose Dysregulation Interacts With APOE-?4 to Potentiate Temporoparietal Cortical Thinning. Am J Alzheimers Dis Other Demen 31:76-86
Stricker, Nikki H; Salat, David H; Kuhn, Taylor P et al. (2016) Mild Cognitive Impairment is Associated With White Matter Integrity Changes in Late-Myelinating Regions Within the Corpus Callosum. Am J Alzheimers Dis Other Demen 31:68-75
Fredman, Lisa; Gordon, Sheryl A; Heeren, Timothy et al. (2014) Positive affect is associated with fewer sleep problems in older caregivers but not noncaregivers. Gerontologist 54:559-69
Foley, Jessica M; Salat, David H; Stricker, Nikki H et al. (2014) Interactive effects of apolipoprotein E4 and diabetes risk on later myelinating white matter regions in neurologically healthy older aged adults. Am J Alzheimers Dis Other Demen 29:222-35
Leritz, Elizabeth C; Shepel, Juli; Williams, Victoria J et al. (2014) Associations between T1 white matter lesion volume and regional white matter microstructure in aging. Hum Brain Mapp 35:1085-100
Morley, John E (2013) Systolic hypertension should not be treated in persons aged 80 and older until blood pressure is greater than 160 mmHg. J Am Geriatr Soc 61:1197-8
Jones, Richard N; Marsiske, Michael; Ball, Karlene et al. (2013) The ACTIVE cognitive training interventions and trajectories of performance among older adults. J Aging Health 25:186S-208S
Stricker, Nikki H; Salat, David H; Foley, Jessica M et al. (2013) Decreased white matter integrity in neuropsychologically defined mild cognitive impairment is independent of cortical thinning. J Int Neuropsychol Soc 19:925-37
Williams, Victoria J; Leritz, Elizabeth C; Shepel, Juli et al. (2013) Interindividual variation in serum cholesterol is associated with regional white matter tissue integrity in older adults. Hum Brain Mapp 34:1826-41
Salat, David H; Williams, Victoria J; Leritz, Elizabeth C et al. (2012) Inter-individual variation in blood pressure is associated with regional white matter integrity in generally healthy older adults. Neuroimage 59:181-92

Showing the most recent 10 out of 118 publications