The bi-institutional Claude D. Pepper Older Americans Independence Center (OAIC) of Bowman Gray School of Medicine of Wake Forest University (BGSM/WFU) and the University of Tennessee-Memphis (UTM) will build upon a tradition of collaborative between the lead investigators at these academic medical centers in the prevention and management of major aging-related chronic diseases and syndromes that jeopardize function as well as longevity in older persons. The administrative and coordinating centers will be based at BGSM/WFU but all of the following activities will take place at both institutions. Specific projects include: 1. One formal intervention study: Therapeutic Exercise for Knee Osteoarthritis 2. Two intervention development studies: a. Osteoporosis: Pharmacologic and Non-pharmacologic interventions b. Trial of Non-Pharmacologic Interventions for Mild Systolic Hypertension in the Elderly (TONE) 3. Research development core: supporting two junior faculty physician investigators who will participate in these intervention trials and two one-year intervention-related pilot studies 4. Three Research Resource Cores a.Recruitment (and recruitment research) b.Biostatistics c.Health quality of life/cost effectiveness 5. Demonstration and Dissemination Core 6. Leadership/Administrative Core These initiatives will build upon strong commitments and investments in developing research faculty and programs in gerontology and geriatrics and the public health sciences at both institutions. Evidence of these commitments and investments include incorporation of a formal course in gerontology and geriatrics in the required undergraduate medical curriculum at BGSM/WFU, required rotations in geriatrics in residences in internal medicine and family medicine at BGSM/WFU, accredited, well-subscribed, and productive geriatric fellowship training programs at both institutions, and a well-developed junior faculty development program at BGSM/WFU. The proposed Pepper OAIC will be fully integrated into these programs consistent with the philosophical basis of program development in gerontology and geriatrics at BGSM/WFU: to imbed these disciplines in the institutional DNA, at it were, to assure their quality, stability and longevity.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Comprehensive Center (P60)
Project #
5P60AG010484-03
Application #
3108080
Study Section
Biological and Clinical Aging Review Committee (BCA)
Project Start
1991-09-30
Project End
1996-06-30
Budget Start
1993-08-10
Budget End
1994-06-30
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
Li, Yanhong; Levy, Wayne C; Neilson, Matthew P et al. (2014) Associations between seattle heart failure model scores and medical resource use and costs: findings from HF-ACTION. J Card Fail 20:541-7
Li, Yanhong; Neilson, Matthew P; Whellan, David J et al. (2013) Associations between Seattle Heart Failure Model scores and health utilities: findings from HF-ACTION. J Card Fail 19:311-6
Flynn, Kathryn E; Lin, Li; Moe, Gordon W et al. (2012) Relationships between changes in patient-reported health status and functional capacity in outpatients with heart failure. Am Heart J 163:88-94.e3
Swank, Ann M; Horton, John; Fleg, Jerome L et al. (2012) Modest increase in peak VO2 is related to better clinical outcomes in chronic heart failure patients: results from heart failure and a controlled trial to investigate outcomes of exercise training. Circ Heart Fail 5:579-85
Miller, G D; Nicklas, B J; Davis, C C et al. (2012) Basal growth hormone concentration increased following a weight loss focused dietary intervention in older overweight and obese women. J Nutr Health Aging 16:169-74
Reed, Shelby D; Li, Yanhong; Dunlap, Mark E et al. (2012) In-hospital resource use and medical costs in the last year of life by mode of death (from the HF-ACTION randomized controlled trial). Am J Cardiol 110:1150-5
Reed, Shelby D; Li, Yanhong; Ellis, Stephen J et al. (2012) Associations between hemoglobin level, resource use, and medical costs in patients with heart failure: findings from HF-ACTION. J Card Fail 18:784-91
Morris, Peter E; Griffin, Leah; Berry, Michael et al. (2011) Receiving early mobility during an intensive care unit admission is a predictor of improved outcomes in acute respiratory failure. Am J Med Sci 341:373-7
Messier, S P; Legault, C; Loeser, R F et al. (2011) Does high weight loss in older adults with knee osteoarthritis affect bone-on-bone joint loads and muscle forces during walking? Osteoarthritis Cartilage 19:272-80
Arena, Ross; Myers, Jonathan; Abella, Joshua et al. (2011) Cardiopulmonary exercise testing is equally prognostic in young, middle-aged and older individuals diagnosed with heart failure. Int J Cardiol 151:278-83

Showing the most recent 10 out of 174 publications