Abstract

The Lifestyles Intervention for Seniors with Arthritis (LISA) Trial is a single-blind, controlled clinical trial to test the efficacy of weight loss on disability and disease progression in older people with knee osteoarthritis. Three hundred obese, sedentary people, age sixty and older, with symptomatic knee osteoarthritis will be randomized to receive: usual care, a structured aerobic exercise intervention, a dietary weight loss intervention or a combined exercise-weight loss intervention. Participants in the study will be followed for thirty months. The primary outcome measure is physical disability. Secondary outcome measures include performance measures of function, exercise capacity, health-related quality of life, biomechanics of gait, knee pain and disease progression by x-ray. The cost effectiveness of the interventions will be determined. This study will determine the relative efficacies of exercise, weight loss and combined intervention in the management of osteoarthritis of the knee in older people.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Comprehensive Center (P60)
Project #
3P60AG010484-08S1
Application #
6217006
Study Section
Project Start
1999-07-20
Project End
2000-06-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
8
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Wake Forest University Health Sciences
Department
Type
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106

  Publications

Li, Yanhong; Levy, Wayne C; Neilson, Matthew P et al. (2014) Associations between seattle heart failure model scores and medical resource use and costs: findings from HF-ACTION. J Card Fail 20:541-7
Li, Yanhong; Neilson, Matthew P; Whellan, David J et al. (2013) Associations between Seattle Heart Failure Model scores and health utilities: findings from HF-ACTION. J Card Fail 19:311-6
Flynn, Kathryn E; Lin, Li; Moe, Gordon W et al. (2012) Relationships between changes in patient-reported health status and functional capacity in outpatients with heart failure. Am Heart J 163:88-94.e3
Swank, Ann M; Horton, John; Fleg, Jerome L et al. (2012) Modest increase in peak VO2 is related to better clinical outcomes in chronic heart failure patients: results from heart failure and a controlled trial to investigate outcomes of exercise training. Circ Heart Fail 5:579-85
Miller, G D; Nicklas, B J; Davis, C C et al. (2012) Basal growth hormone concentration increased following a weight loss focused dietary intervention in older overweight and obese women. J Nutr Health Aging 16:169-74
Reed, Shelby D; Li, Yanhong; Dunlap, Mark E et al. (2012) In-hospital resource use and medical costs in the last year of life by mode of death (from the HF-ACTION randomized controlled trial). Am J Cardiol 110:1150-5
Reed, Shelby D; Li, Yanhong; Ellis, Stephen J et al. (2012) Associations between hemoglobin level, resource use, and medical costs in patients with heart failure: findings from HF-ACTION. J Card Fail 18:784-91
Morris, Peter E; Griffin, Leah; Berry, Michael et al. (2011) Receiving early mobility during an intensive care unit admission is a predictor of improved outcomes in acute respiratory failure. Am J Med Sci 341:373-7
Messier, S P; Legault, C; Loeser, R F et al. (2011) Does high weight loss in older adults with knee osteoarthritis affect bone-on-bone joint loads and muscle forces during walking? Osteoarthritis Cartilage 19:272-80
Arena, Ross; Myers, Jonathan; Abella, Joshua et al. (2011) Cardiopulmonary exercise testing is equally prognostic in young, middle-aged and older individuals diagnosed with heart failure. Int J Cardiol 151:278-83

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