Abstract

This application is for renewal of the University of Virginia Diabetes Research and Training Center. Funding is requested for the existing administrative, Radio Immunoassay and Ligand Preparation, Tissue Culture, Electron Microscopy, Biomathematics, and Outreach Cores. The application proposes three new cores, Membrane Preparation, Protein Sequencing, and Model Demonstration Unit, and ten new initiative studies. In addition, the application describes numerous research trainings professional training, model demonstration and outreach activities which are funded from sources other than the DRTC grant.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases (NIADDK)
Type
Comprehensive Center (P60)
Project #
5P60AM022125-08
Application #
3108131
Study Section
(SRC)
Project Start
1978-09-30
Project End
1986-09-29
Budget Start
1985-04-01
Budget End
1986-09-29
Support Year
8
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Virginia
Department
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904

  Publications

Iranmanesh, A; Lizarralde, G; Veldhuis, J D (1993) Coordinate activation of the corticotropic axis by insulin-induced hypoglycemia: simultaneous estimates of beta-endorphin, adrenocorticotropin and cortisol secretion and disappearance in normal men. Acta Endocrinol (Copenh) 128:521-8
Iranmanesh, A; Lizarralde, G; Veldhuis, J D (1992) Robustness of the male lactotropic axis to the hyperprolactinemic stimulus of primary thyroidal failure. J Clin Endocrinol Metab 74:559-64
Johnson, M L (1992) Analysis of ligand-binding data with experimental uncertainties in independent variables. Methods Enzymol 210:106-17
Crane, J K; Wehner, M S; Bolen, E J et al. (1992) Regulation of intestinal guanylate cyclase by the heat-stable enterotoxin of Escherichia coli (STa) and protein kinase C. Infect Immun 60:5004-12
Veldhuis JDP6; Blizzard, R M; Rogol, A D et al. (1992) Properties of spontaneous growth hormone secretory bursts and half-life of endogenous growth hormone in boys with idiopathic short stature. Genentech Collaborative Group. J Clin Endocrinol Metab 74:766-73
Clarke, W L; Gonder-Frederick, L A; Richards, F E et al. (1991) Multifactorial origin of hypoglycemic symptom unawareness in IDDM. Association with defective glucose counterregulation and better glycemic control. Diabetes 40:680-5
Gonder-Frederick, L A; Snyder, A L; Clarke, W L (1991) Accuracy of blood glucose estimation by children with IDDM and their parents. Diabetes Care 14:565-70
Cox, D J; Gonder-Frederick, L; Julian, D et al. (1991) Intensive versus standard blood glucose awareness training (BGAT) with insulin-dependent diabetes: mechanisms and ancillary effects. Psychosom Med 53:453-62
Sortino, M A; Delahunty, T M; Yasumoto, T et al. (1991) Maitotoxin increases inositol phosphates in rat anterior pituitary cells. J Mol Endocrinol 6:95-9
Urban, R J; Veldhuis, J D; Dufau, M L (1991) Estrogen regulates the gonadotropin-releasing hormone-stimulated secretion of biologically active luteinizing hormone. J Clin Endocrinol Metab 72:660-8

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