Fracture of the hip is a frequent cause of disability among elderly patients. Many patients fail to achieve functional recovery and incur long-term institutionalizations following a hospitalization for a hip fracture. Although several factors have been found to be associated with functional recovery among patients requiring nursing home care after a hip fracture, an examination of the effect of strength on recovery is lacking. We propose a prospective study to examine effect of upper extremity and lower extremity muscular strength on the outcomes of elderly patients who are admitted to nursing homes after an acute hospitalization for a fracture of the hip.
We aim to 1) determine the functional outcomes of elderly patients who are admitted to nursing homes in Central Indiana after an acute hospitalization for a hip fracture and 2) to determine the effect of muscle strength and changes in strength on functional recovery. A cohort study design will be used to achieve these aims. Patients admitted to a nursing home immediately after a hospitalization for a fractured hip will be identified. Consecutive, eligible, consenting patients will be prospectively enrolled during thirty-six calendar months and followed for one year. Baseline assessments of patient's upper and lower extremity strength, demographic, clinical, social, and functional status characteristics at the time of admission to the nursing home will be performed. At intervals of 3 and 6 months, strength will be remeasured and functional status will be reassessed. At 12 months after enrollment, strength will be remeasured and the clinical, psychosocial, and functional status characteristics will be reassessed. We hope to determine whether strength or changes in strength is associated with functional recovery of these patients with hip fractures.

Project Start
Project End
Budget Start
Budget End
Support Year
18
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Mazzuca, Steven A; Brandt, Kenneth D; Katz, Barry P et al. (2007) Risk factors for early radiographic changes of tibiofemoral osteoarthritis. Ann Rheum Dis 66:394-9
Merle-Vincent, F; Vignon, E; Brandt, K et al. (2007) Superiority of the Lyon schuss view over the standing anteroposterior view for detecting joint space narrowing, especially in the lateral tibiofemoral compartment, in early knee osteoarthritis. Ann Rheum Dis 66:747-53
Otterness, Ivan G; Brandt, Kenneth D; Le Graverand, Marie-Pierre Hellio et al. (2007) Urinary TIINE concentrations in a randomized controlled trial of doxycycline in knee osteoarthritis: implications of the lack of association between TIINE levels and joint space narrowing. Arthritis Rheum 56:3644-9
Mikesky, Alan E; Mazzuca, Steven A; Brandt, Kenneth D et al. (2006) Effects of strength training on the incidence and progression of knee osteoarthritis. Arthritis Rheum 55:690-9
Hellio Le Graverand, M-P; Brandt, K D; Mazzuca, S A et al. (2006) Association between concentrations of urinary type II collagen neoepitope (uTIINE) and joint space narrowing in patients with knee osteoarthritis. Osteoarthritis Cartilage 14:1189-95
Mazzuca, S A; Brandt, K D; Eyre, D R et al. (2006) Urinary levels of type II collagen C-telopeptide crosslink are unrelated to joint space narrowing in patients with knee osteoarthritis. Ann Rheum Dis 65:1055-9
Brandt, Kenneth D; Mazzuca, Steven A (2006) Experience with a placebo-controlled randomized clinical trial of a disease-modifying drug for osteoarthritis: the doxycycline trial. Rheum Dis Clin North Am 32:217-34, xi-xii
Mazzuca, S A; Brandt, K D; Katz, B P et al. (2006) Comparison of quantitative and semiquantitative indicators of joint space narrowing in subjects with knee osteoarthritis. Ann Rheum Dis 65:64-8
Mazzuca, Steven A; Poole, A Robin; Brandt, Kenneth D et al. (2006) Associations between joint space narrowing and molecular markers of collagen and proteoglycan turnover in patients with knee osteoarthritis. J Rheumatol 33:1147-51
Brandt, Kenneth D; Mazzuca, Steven A; Katz, Barry P et al. (2005) Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial. Arthritis Rheum 52:2015-25

Showing the most recent 10 out of 162 publications