Abstract

The Molecular Medicine Core is proposed as a key facility which will both facilitate and augment biomedical research in the MAMDC. The Core has four subunits: Polymerase Chain Reaction (PCR) Unit, Differential Display Unit, Immunocytochemistry Facility and In Situ Hybridization Unit. Each unit embodies technological approaches which are needed and used by multiple investigators but which benefit from centralization and special expertise, the latter not necessarily possessed to an adequate extent by all investigators. The Core will thus make available state of the art technologies in molecular medicine to all investigators in the MAMDC. The Molecular Medicine Core will be directed by Dr. Joseph Kom who will have overall scientific and administrative responsibility. The Units are each directed by capable and innovative molecular and cell biologists with experience in the requisite methodologies. A mechanism for evaluation and review of core functions is proposed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
5P60AR020613-21
Application #
6100342
Study Section
Project Start
1998-09-01
Project End
1999-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
21
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Boston University
Department
Type
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Stefanik, J J; Niu, J; Gross, K D et al. (2013) Using magnetic resonance imaging to determine the compartmental prevalence of knee joint structural damage. Osteoarthritis Cartilage 21:695-9
Allaire, Saralynn H; Li, Wei; LaValley, Michael P (2003) Reduction of job loss in persons with rheumatic diseases receiving vocational rehabilitation: a randomized controlled trial. Arthritis Rheum 48:3212-8
Formica, Margaret K; Palmer, Julie R; Rosenberg, Lynn et al. (2003) Smoking, alcohol consumption, and risk of systemic lupus erythematosus in the Black Women's Health Study. J Rheumatol 30:1222-6
McAlindon, T E; Formica, M; Palmer, J R et al. (2003) Assessment of strategies for identifying diagnosed cases of systemic lupus erythematosus through self-report. Lupus 12:754-9
Samelson, Elizabeth J; Zhang, Yuqing; Kiel, Douglas P et al. (2002) Effect of birth cohort on risk of hip fracture: age-specific incidence rates in the Framingham Study. Am J Public Health 92:858-62
Demissie, S; Cupples, L A; Myers, R et al. (2002) Genome scan for quantity of hand osteoarthritis: the Framingham Study. Arthritis Rheum 46:946-52
Nevitt, Michael C; Xu, Ling; Zhang, Yuqing et al. (2002) Very low prevalence of hip osteoarthritis among Chinese elderly in Beijing, China, compared with whites in the United States: the Beijing osteoarthritis study. Arthritis Rheum 46:1773-9
Felson, David T; Anderson, Jennifer J (2002) Hyaluronate sodium injections for osteoarthritis: hope, hype, and hard truths. Arch Intern Med 162:245-7
Yoshida, Shoji; Aoyagi, Kiyoshi; Felson, David T et al. (2002) Comparison of the prevalence of radiographic osteoarthritis of the knee and hand between Japan and the United States. J Rheumatol 29:1454-8
Kerrigan, D Casey; Lelas, Jennifer L; Goggins, Joyce et al. (2002) Effectiveness of a lateral-wedge insole on knee varus torque in patients with knee osteoarthritis. Arch Phys Med Rehabil 83:889-93

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