Abstract

Rheumatoid arthritis (RA) is an inflammatory disease associated with intense angiogenesis. The outcome of angiogenesis highly depends on the balance between activity of pro-angiogenic and anti-angiogenic factors. New improved methods for preventing and treating RA and other diseases that are associated with angiogenesis require an understanding of factors that regulate this balance. Recent discovery by our laboratory demonstrates that cadherin-5 (also called VE-cadherin) and VEGFR-1 (one of the receptors for VEGF) have the potential to inhibit vascular endothelial growth factor receptor-2 (VEGFR-2) mediated endothelial cell proliferation, the most well-characterized receptor in angiogenesis. These findings suggest a central role for cadherin-5 and VEGFR-1 in regulating angiogenesis. The central hypothesis of this proposal is that vascular endothelial growth factor (VEGF) is responsible for angiogenesis of RA and that Cadherin-5 and VEGFR-1 may act as an anti-angiogenic factors in this process. To test this hypothesis the following specific aims are proposed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
5P60AR020613-23
Application #
6354459
Study Section
Special Emphasis Panel (ZAR1-AAA-C (O1))
Project Start
1977-09-20
Project End
2001-08-31
Budget Start
Budget End
Support Year
23
Fiscal Year
2000
Total Cost
$197,140
Indirect Cost

  Institution

Name
Boston University
Department
Type
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Stefanik, J J; Niu, J; Gross, K D et al. (2013) Using magnetic resonance imaging to determine the compartmental prevalence of knee joint structural damage. Osteoarthritis Cartilage 21:695-9
Allaire, Saralynn H; Li, Wei; LaValley, Michael P (2003) Reduction of job loss in persons with rheumatic diseases receiving vocational rehabilitation: a randomized controlled trial. Arthritis Rheum 48:3212-8
Formica, Margaret K; Palmer, Julie R; Rosenberg, Lynn et al. (2003) Smoking, alcohol consumption, and risk of systemic lupus erythematosus in the Black Women's Health Study. J Rheumatol 30:1222-6
McAlindon, T E; Formica, M; Palmer, J R et al. (2003) Assessment of strategies for identifying diagnosed cases of systemic lupus erythematosus through self-report. Lupus 12:754-9
Samelson, Elizabeth J; Zhang, Yuqing; Kiel, Douglas P et al. (2002) Effect of birth cohort on risk of hip fracture: age-specific incidence rates in the Framingham Study. Am J Public Health 92:858-62
Demissie, S; Cupples, L A; Myers, R et al. (2002) Genome scan for quantity of hand osteoarthritis: the Framingham Study. Arthritis Rheum 46:946-52
Nevitt, Michael C; Xu, Ling; Zhang, Yuqing et al. (2002) Very low prevalence of hip osteoarthritis among Chinese elderly in Beijing, China, compared with whites in the United States: the Beijing osteoarthritis study. Arthritis Rheum 46:1773-9
Felson, David T; Anderson, Jennifer J (2002) Hyaluronate sodium injections for osteoarthritis: hope, hype, and hard truths. Arch Intern Med 162:245-7
Yoshida, Shoji; Aoyagi, Kiyoshi; Felson, David T et al. (2002) Comparison of the prevalence of radiographic osteoarthritis of the knee and hand between Japan and the United States. J Rheumatol 29:1454-8
Kerrigan, D Casey; Lelas, Jennifer L; Goggins, Joyce et al. (2002) Effectiveness of a lateral-wedge insole on knee varus torque in patients with knee osteoarthritis. Arch Phys Med Rehabil 83:889-93

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