Five years of funding (Years 15-19) are requested for the renewal of the MAC with Dr. Rothfield as Director and Dr. Abeles as Associate Director. The Research Component will continue under the direction of Dr. Korn. Five D/Fs are proposed: D/F1-A Transgenic Approach to the Mechanism of Tissue Destruction in Arthritis - M. Hibbs, M.D.; D/F2 - The Role of Gamma/Delta T Cells in Collagen Induced Arthritis - L. Lefrancois, Ph.D.; D/F3 - Effects of Anti-Inflammatory Drugs on Lymphocyte Adhesion - T. Piela-Smith, Ph.D.; D/F4 - Effect of Implant Materials on Human Osteoblast Cultures - G. Gronowicz, Ph.D.; D/F5 - Evaluation of the Tight Skin Mutation in Chimeric Mice - S. Clark, Ph.D. The Education, Epidemiology, Health Services Research Component will continue under the direction of Susan Reisine, Ph.D. Activities will be coordinated by Frances Ingenito, N.P. and carried out by the MAC faculty and the Teaching Team. Dr. Parke will continue as the Physician Education Coordinator with Robert Rippey, Ph.D. as consultant. Two Research Projects and one D/F are proposed: Project 1 - Daily Processes in Primary Fibromyalgia - Glenn Affleck, Ph.D.; Project 2 - A National Study of Role Limitations in Rheumatoid Arthritis Patients - Susan Reisine, Ph.D.; D/F1 - A Work Stress Instrument: Development and Evaluation - is requested for data acquisition and analysis for the component projects and D/F and to make our existing data sets available to others. Renewal of the Statistics and Database Core under the direction of Jonathan Clive, Ph.D. is requested to provide statistics, database and epidemiology support and expertise for ongoing and proposed research. An Administrative Unit will continue the overall administration of the Center.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
5P60AR020621-16
Application #
2078478
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1978-09-30
Project End
1997-12-31
Budget Start
1994-01-01
Budget End
1994-12-31
Support Year
16
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Connecticut
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Farmington
State
CT
Country
United States
Zip Code
06030
Reisine, S; Fifield, J; Walsh, S et al. (2007) Work disability among two cohorts of women with recent-onset rheumatoid arthritis: a survival analysis. Arthritis Rheum 57:372-80
Jump, Rebecca L; Fifield, Judith; Tennen, Howard et al. (2004) History of affective disorder and the experience of fatigue in rheumatoid arthritis. Arthritis Rheum 51:239-45
McQuillan, Julia; Fifield, Judith; Sheehan, T Joseph et al. (2003) A comparison of self-reports of distress and affective disorder diagnoses in rheumatoid arthritis: a receiver operator characteristic analysis. Arthritis Rheum 49:368-76
Reisine, S; Fifield, J; Walsh, S J et al. (2001) Factors associated with continued employment among patients with rheumatoid arthritis: a survival model. J Rheumatol 28:2400-8
Affleck, G; Tennen, H; Zautra, A et al. (2001) Women's pursuit of personal goals in daily life with fibromyalgia: a value-expectancy analysis. J Consult Clin Psychol 69:587-96
Tennen, H; Affleck, G; Armeli, S et al. (2000) A daily process approach to coping. Linking theory, research, and practice. Am Psychol 55:626-36
Reisine, S; Fifield, J; Winkelman, D K (2000) Characteristics of rheumatoid arthritis patients: who participates in long-term research and who drops out? Arthritis Care Res 13:10-Mar
Gorin, A A; Smyth, J M; Weisberg, J N et al. (1999) Rheumatoid arthritis patients show weather sensitivity in daily life, but the relationship is not clinically significant. Pain 81:173-7
Walsh, S J (1999) Effects of non-mining occupational silica exposure on proportional mortality from silicosis and systemic sclerosis. J Rheumatol 26:2179-85
Cowles, E A; DeRome, M E; Pastizzo, G et al. (1998) Mineralization and the expression of matrix proteins during in vivo bone development. Calcif Tissue Int 62:74-82

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