The major goals of the Multipurpose Arthritis and Musculoskeletal Diseases Center (MAMDC) at UCSF are: (i) to conduct basic research in areas related to the etiology and pathogenesis of arthritis and musculoskeletal diseases (A&MDs), (ii) to conduct research regarding the epidemiology of A&MDs, (iii) to develop and evaluated new methods for the prevention, diagnosis, and treatment of A&MDs, (iv) to train biomedical scientists, physicians, and other health professionals whose work bears on the problems of patients, physicians, and other health educational programs in the field of A&MDs for physicians, for allied health professionals, and for patients, and (vi) to work with local, and state and national organizations for the purpose of advancing knowledge of A&MDs and promoting care of patients with these diseases. Patient care is not direct objective of the MAMDC, but the activities of the MAMDC are conducted in centers where patient care is a primary concern and fundamental goal of the institutions. To meet these objectives, comprehensive programs have been developed at the three major teaching hospitals of the University: Moffitt-Long, the San Francisco Department of Veterans Affairs Medical Center, and the San Francisco General Hospital. Each of these brings unique resources to the MAMDC. The Center has functioned in a manner that utilizes each and, by fostering interaction among them, has developed programs that could not have succeeded at a single institution. The Biomedical Research Program of the MAMDC at UCSF encompasses a broad range of basic research activities that are fully funded from other sources. This has proved a fertile ground for the success of D&F studies and for the training of young investigators. Six D&F studies are proposed as part of this project: four for junior investigators, one for an investigator in another area to begin research related to A&MDs and one for an established investigator to help begin a new area of research. The Education, Epidemiology, and Health Services Research Component has developed a strong program focused on the problems of patients with A&MDs. Six projects and one Core Unit are proposed as part of this project for the collection and maintenance of data regarding a local cohort of patients with RA and regarding controls.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
2P60AR020684-17
Application #
2078482
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1977-09-15
Project End
1998-12-31
Budget Start
1994-01-01
Budget End
1994-12-31
Support Year
17
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Briggs, F B S; Ramsay, P P; Madden, E et al. (2010) Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis. Genes Immun 11:199-208
Yazdany, Jinoos; Yelin, Edward (2010) Health-related quality of life and employment among persons with systemic lupus erythematosus. Rheum Dis Clin North Am 36:15-32, vii
Janssens, A Cecile J W; Steyerberg, Ewout W; Jiang, Yebin et al. (2006) Value of the HLA-DRB1 shared epitope for predicting radiographic damage in rheumatoid arthritis depends on the individual patient risk profile. J Rheumatol 33:2383-9
Katz, Patricia P (2006) Childbearing decisions and family size among women with rheumatoid arthritis. Arthritis Rheum 55:217-23
Yelin, Edward H; Trupin, Laura S; Katz, Patricia P (2005) Impact of managed care on the use of biologic agents for rheumatoid arthritis. Arthritis Rheum 53:423-30
Katz, Patricia P (2005) Use of self-management behaviors to cope with rheumatoid arthritis stressors. Arthritis Rheum 53:939-49
von Scheven, E; Elder, M E (2005) Association between beta2-glycoprotein I gene polymorphisms and pediatric SLE and antiphospholipid antibodies. Lupus 14:440-4
Yang, Nan; Li, Hongzhe; Criswell, Lindsey A et al. (2005) Examination of ancestry and ethnic affiliation using highly informative diallelic DNA markers: application to diverse and admixed populations and implications for clinical epidemiology and forensic medicine. Hum Genet 118:382-92
Seldin, Michael F; Morii, Takanobu; Collins-Schramm, Heather E et al. (2004) Putative ancestral origins of chromosomal segments in individual african americans: implications for admixture mapping. Genome Res 14:1076-84
Chang, Wenhan; Shoback, Dolores (2004) Extracellular Ca2+-sensing receptors--an overview. Cell Calcium 35:183-96

Showing the most recent 10 out of 111 publications