The MAC at Northwestern University is a truly multidisciplinary program that operates as an integrated unit under the leadership of the above-named professionals to address a broad range of research and training activities. Biomedical Research. The major focus is the study of immune- mediated inflammation in rheumatic disease. Five developmental/feasability projects cover this area: characterization of T-cell receptors of rheumatoid synovial lymphocytes to type II collagen (DF1); IL-1 and B-cell growth factor production by synovial large granular lymphocytes (DF2); macrophage heterogeneity in rheumatoid synovium (DF3); biology of CRP in rheumatoid synovium (DF4); and effect of adjuvant- induced arthritis on systemic bone mineralization (DF5). A second focus involves infectious agents in rheumatic diseases: one project will search for a retrovirus etiology in Kawasaki's disease (DF6). The third focus is the reconstruction of damaged joints: one project will study the strength of the cement/bone interface in cemented prostheses (DF7). Non-biomedical Research. Changing patterns of health care are being investigated for the effect of HMO growth upon referral utilization to the rheumatology subspecialist (C3); the cost effectiveness of rheumatologists as primary care providers for rheumatoid arthritis patients (C2); and the use of management technique, the Critical Path Method, to control inpatient costs of arthritis rehabilitation (C4). Children and the aged with musculoskeletal disease are being studied: children to treat pain with psychological approaches (C5) and to better understand their pain experience (C6); and a large cohort of aged to document the trajectory of functional status decline, health care utilization and costs (C1). Controlled prospective studies of treatment build upon current experience: the first looks at the effect of a shoe orthosis in rheumatoid arthritis (C7); and the second upon the effect of ultrasound therapy on knee contractures in osteoarthritis (C8). The education area extends current work in problem-solving education strategies; low impact aerobic exercise for arthritics and trained patient instructors to explore innovative educational methods for allied health professionals (E2); and a new ambulatory rheumatology elective for senior medical students (E1). Biostatistical and Data Management Core. This unit - a vital support for projects and a means to strengthen bonds among MAC investigators - provides services for all components of the MAC.

Project Start
1983-12-01
Project End
1991-11-30
Budget Start
1988-12-01
Budget End
1989-11-30
Support Year
6
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Poornima, I G; Shields, K; Kuller, L H et al. (2018) Associations of osteoprotegerin with coronary artery calcification among women with systemic lupus erythematosus and healthy controls. Lupus :961203317751060
Demirci, F Yesim; Wang, Xingbin; Morris, David L et al. (2017) Multiple signals at the extended 8p23 locus are associated with susceptibility to systemic lupus erythematosus. J Med Genet 54:381-389
Demirci, F Yesim; Wang, Xingbin; Kelly, Jennifer A et al. (2016) Identification of a New Susceptibility Locus for Systemic Lupus Erythematosus on Chromosome 12 in Individuals of European Ancestry. Arthritis Rheumatol 68:174-83
Zhao, Jian; Giles, Brendan M; Taylor, Rhonda L et al. (2016) Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA. Ann Rheum Dis 75:242-52
Kottyan, Leah C; Zoller, Erin E; Bene, Jessica et al. (2015) The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share. Hum Mol Genet 24:582-96
Parker, Ben; Urowitz, Murray B; Gladman, Dafna D et al. (2015) Impact of early disease factors on metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort. Ann Rheum Dis 74:1530-6
Martins, M; Williams, A H; Comeau, M et al. (2015) Genetic association of CD247 (CD3?) with SLE in a large-scale multiethnic study. Genes Immun 16:142-50
Bernatsky, Sasha; Ramsey-Goldman, Rosalind; Joseph, Lawrence et al. (2014) Lymphoma risk in systemic lupus: effects of disease activity versus treatment. Ann Rheum Dis 73:138-42
Lertratanakul, Apinya; Wu, Peggy; Dyer, Alan R et al. (2014) Risk factors in the progression of subclinical atherosclerosis in women with systemic lupus erythematosus. Arthritis Care Res (Hoboken) 66:1177-85
Kaiser, Rachel; Tang, Ling Fung; Taylor, Kimberly E et al. (2014) A polymorphism in TLR2 is associated with arterial thrombosis in a multiethnic population of patients with systemic lupus erythematosus. Arthritis Rheumatol 66:1882-7

Showing the most recent 10 out of 248 publications