Persistent musculoskeletal pain plagues approximately 50% of community dwelling older adults, and causes physical, psychosocial and cognitive dysfunction. Despite the prevalence of this potentially devastating problem, well controlled studies of persistent pain in older adults that utilize a comprehensive multidisciplinary model of outcome to assess treatment efficacy are lacking. Existing studies include subjects with heterogeneous pathology, have inadequate control groups, measure the response to treatment using self-report as opposed to actual measures of physical performance, and do not include measures of cognitive performance. In addition, treatment interventions in previous studies have not been rigorous. The purpose of the proposed research is to use persistent low back pain related to osteoarthritis (OA) treated using percutaneous electrical nerve stimulation (PENS) as a model for examining the multidisciplinary effects of persistent pain treatment in the older adult. In addition, by using a non-pharmacologic intervention, we will be able to examine the effects of pain per se and its improvement with treatment on physical, psychosocial and cognitive performance. It has recently been suggested that PENS, which utilizes acupuncture needles plus electrical current, may be superior to acupuncture alone to treat low back pain. Using a randomized controlled experimental design, 20 community dwelling older adults greater than age 65 with persistent low back pain and lumbosacral osteoarthritis, but without other functionally limiting pain conditions, will receive physical therapy plus PENS, twice a week for 6 weeks, and 20 subjects will receive physical therapy plus sham PENS. Effects on pain intensity, sleep, cognitive function, mood, physical performance, and interference with performance of everyday tasks will be assessed at baseline, at the completion of treatment and 3 months later. If beneficial, this pilot study could lead to a variety of definitive investigative efforts geared toward developing more effective strategies to treat and understand the treatment responses of persistent OA-associated low back pain in older adults.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
5P60AR044811-03
Application #
6210914
Study Section
Special Emphasis Panel (ZAR1-AAA-C (O1))
Project Start
1997-09-25
Project End
2001-08-31
Budget Start
Budget End
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Kao, Amy H; Lertratanakul, Apinya; Elliott, Jennifer R et al. (2013) Relation of carotid intima-media thickness and plaque with incident cardiovascular events in women with systemic lupus erythematosus. Am J Cardiol 112:1025-32
Kao, Amy H; Wasko, Mary Chester M; Krishnaswami, Shanthi et al. (2008) C-reactive protein and coronary artery calcium in asymptomatic women with systemic lupus erythematosus or rheumatoid arthritis. Am J Cardiol 102:755-60
Sheu, Yah-Tyng; Zmuda, Joseph M; Cauley, Jane A et al. (2006) Nuclear receptor coactivator-3 alleles are associated with serum bioavailable testosterone, insulin-like growth factor-1, and vertebral bone mass in men. J Clin Endocrinol Metab 91:307-12
Faulkner, K A; Cauley, J A; Zmuda, J M et al. (2006) Higher 1,25-dihydroxyvitamin D3 concentrations associated with lower fall rates in older community-dwelling women. Osteoporos Int 17:1318-28
Cauley, Jane A; Lui, Li-Yung; Stone, Katie L et al. (2005) Longitudinal study of changes in hip bone mineral density in Caucasian and African-American women. J Am Geriatr Soc 53:183-9
Cauley, Jane A; Lui, Li-Yung; Ensrud, Kristine E et al. (2005) Bone mineral density and the risk of incident nonspinal fractures in black and white women. JAMA 293:2102-8
Walsh, Sean; Zmuda, Joseph M; Cauley, Jane A et al. (2005) Androgen receptor CAG repeat polymorphism is associated with fat-free mass in men. J Appl Physiol 98:132-7
Riechman, Steven E; Balasekaran, G; Roth, Stephen M et al. (2004) Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses. J Appl Physiol 97:2214-9
Cauley, Jane A; Zmuda, Joseph M; Wisniewski, Stephen R et al. (2004) Bone mineral density and prevalent vertebral fractures in men and women. Osteoporos Int 15:32-7
Roth, Stephen M; Zmuda, Joseph M; Cauley, Jane A et al. (2004) Vitamin D receptor genotype is associated with fat-free mass and sarcopenia in elderly men. J Gerontol A Biol Sci Med Sci 59:10-5

Showing the most recent 10 out of 60 publications