The long-term goal of this project is to develop a better understanding of the effects of diminished linguistic experience on language development. The specific model to b tested, termed the 'phonological base hypothesis' (PBH), suggests that children who suffer diminished linguistic experience show delays in phonological development, and that these delays explain delays in language (i.e., syntactic) development. This model evolved from two sources: (1) work by the PI showing a developmental shift in the perceptual weights assigned to acoustic speech parameters and suggesting that this shift is correlated with the development of phonological awareness; and (2) work by others showing that poor phonological awareness is correlated with poor comprehension of complex syntax. An alternative hypothesis to be tested is that children with diminished linguistic experience will show deficiencies in general auditory-processing abilities, and that these deficiencies will explain their delays in language development. Experiments will be conducted with three groups of children thought to suffer diminished linguistic experience (children with histories of chronic otitis media, children from low socioeconomic environments, and hearing-impaired children) and a group of control children.
Five Specific Aims will test the hypotheses that children with diminished linguistic experience show delays in the development of mature weighting strategies and in phonological awareness; that delays in the development of these skills result in problems with the comprehension of complex syntax; that early, short-lived deficits in linguistic experience can be overcome, if later experience is adequate and appropriate; that conditions that diminish linguistic experience are additive in their effects; and that delays in phonological or language development are not due to differences in general auditory processing. Results should have implications for the medical and behavioral treatment of children with otitis media, children living in low socioeconomic environments, and hearing-impaired children.

Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Father Flanagan's Boys' Home
Department
Type
DUNS #
City
Boys Town
State
NE
Country
United States
Zip Code
68010
Song, Lei; McGee, Joann; Walsh, Edward J (2008) The influence of thyroid hormone deficiency on the development of cochlear nonlinearities. J Assoc Res Otolaryngol 9:464-76
Song, Lei; McGee, JoAnn; Walsh, Edward J (2008) Development of cochlear amplification, frequency tuning, and two-tone suppression in the mouse. J Neurophysiol 99:344-55
Varga, R; Avenarius, M R; Kelley, P M et al. (2006) OTOF mutations revealed by genetic analysis of hearing loss families including a potential temperature sensitive auditory neuropathy allele. J Med Genet 43:576-81
Song, Lei; McGee, Jo Ann; Walsh, Edward J (2006) Consequences of combined maternal, fetal and persistent postnatal hypothyroidism on the development of auditory function in Tshrhyt mutant mice. Brain Res 1101:59-72
Song, Lei; McGee, Joann; Walsh, Edward J (2006) Frequency- and level-dependent changes in auditory brainstem responses (ABRS) in developing mice. J Acoust Soc Am 119:2242-57
Higgins, Maureen B; McCleary, Elizabeth A; Ide-Helvie, Dana L et al. (2005) Speech and voice physiology of children who are hard of hearing. Ear Hear 26:546-58
Pennings, Ronald J E; Topsakal, Vedat; Astuto, Lisa et al. (2004) Variable clinical features in patients with CDH23 mutations (USH1D-DFNB12). Otol Neurotol 25:699-706
Varga, R; Kelley, P M; Keats, B J et al. (2003) Non-syndromic recessive auditory neuropathy is the result of mutations in the otoferlin (OTOF) gene. J Med Genet 40:45-50
Higgins, Maureen B; McCleary, Elizabeth A; Carney, Arlene Earley et al. (2003) Longitudinal changes in children's speech and voice physiology after cochlear implantation. Ear Hear 24:48-70
Bhattacharya, Gautam; Miller, Caroline; Kimberling, William J et al. (2002) Localization and expression of usherin: a novel basement membrane protein defective in people with Usher's syndrome type IIa. Hear Res 163:1-11

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