The Clinical Core will support clinical and translational activities of the proposed Oral Cancer Center. The goals of the Core are: 1. To identify patients who are candidates for participation in clinical trials and research projects proposed as a part of this application and those that will be initiated at the Center in the future. 2. To assist in obtaining informed consent and to administer clinical and demographic questionnaires, including information on the risk factors for oral cancer, to patients selected to participate in the Center's clinical trials or research protocols. 3. To organize and implement the flow of patient-relevant information and clinical data necessary to support the on-going and future clinical and translational projects. 4. To implement therapeutic and monitoring procedures for patients on clinical protocols, including clinical follow-up and documentation of clinical data according to the protocol. 5. To provide basic researchers participating in the Center's studies with adequate clinical material in the form of tissue or blood samples to fulfill the objectives of each project.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Comprehensive Center (P60)
Project #
5P60DE013059-03
Application #
6480420
Study Section
Project Start
2001-08-01
Project End
2002-07-31
Budget Start
Budget End
Support Year
3
Fiscal Year
2001
Total Cost
$159,355
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Sobo-Vujanovic, Andrea; Munich, Stephan; Vujanovic, Nikola L (2014) Dendritic-cell exosomes cross-present Toll-like receptor-ligands and activate bystander dendritic cells. Cell Immunol 289:119-27
Baskic, Dejan; Vujanovic, Lazar; Arsenijevic, Nebojsa et al. (2013) Suppression of natural killer-cell and dendritic-cell apoptotic tumoricidal activity in patients with head and neck cancer. Head Neck 35:388-98
Wan, Xiao Chloe; Egloff, Ann Marie; Johnson, Jonas (2012) Histological assessment of cervical lymph node identifies patients with head and neck squamous cell carcinoma (HNSCC): who would benefit from chemoradiation after surgery? Laryngoscope 122:2712-22
Zhong, Shilong; Nukui, Tomoko; Buch, Shama et al. (2011) Effects of ERCC2 Lys751Gln (A35931C) and CCND1 (G870A) polymorphism on outcome of advanced-stage squamous cell carcinoma of the head and neck are treatment dependent. Cancer Epidemiol Biomarkers Prev 20:2429-37
Ge, Lisheng; Baskic, Dejan; Basse, Per et al. (2009) Sheddase activity of tumor necrosis factor-alpha converting enzyme is increased and prognostically valuable in head and neck cancer. Cancer Epidemiol Biomarkers Prev 18:2913-22
Martin, Christa Lese; Reshmi, Shalini C; Ried, Thomas et al. (2008) Chromosomal imbalances in oral squamous cell carcinoma: examination of 31 cell lines and review of the literature. Oral Oncol 44:369-82
Buch, Shama C; Nazar-Stewart, Valle; Weissfeld, Joel L et al. (2008) Case-control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymes. Head Neck 30:1139-47
White, Jason S; Weissfeld, Joel L; Ragin, Camille C R et al. (2007) The influence of clinical and demographic risk factors on the establishment of head and neck squamous cell carcinoma cell lines. Oral Oncol 43:701-12
Xu, Jun; Chakrabarti, Ayan K; Tan, Jennifer L et al. (2007) Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell-natural killer cell crosstalk. Blood 109:3333-41
Makarenkova, Valeria; Chakrabarti, Ayan K; Liberatore, Jennifer A et al. (2005) Dendritic cells and natural killer cells interact via multiple TNF family molecules. J Leukoc Biol 77:408-13

Showing the most recent 10 out of 39 publications