It is now accepted that effective treatment of diabetes reduces the incidence and severity of its complications. Our research and that of others confirm that most patients with diabetes are not receiving adequate care, emphasizing the need for earlier diagnosis and treatment. With this in mind, we have adopted as the theme of this DRTC Shifting the Curve: Preventing Diabetes and Its Complications. The Indiana University DRTC enhances diabetes research through support of Research Enrichment, Pilot Projects, Research Training and Core facilities. The research base consists of 53 primary investigators with annual direct funding of $12,324,577 and 32 Collaborating investigators with an additional $11,889,534. These investigators fall into four groups: Molecular and Cell Biology, Complications, Physiology, and Health Service Research. The Molecular and Cell Biology Group has strengths in metabolism and signal transduction, and is supported primarily by the molecular Biology Core. The Complications Group focuses on molecular mechanisms of vascular disease and other end-organ diabetic complications. It is supported by the Biostatistics, Immunologic services, Molecular Biology and Physiology Cores. The Physiology Group is expanding our knowledge of the pathophysiology of diabetes and insulin resistance. Several newly recruited investigators add expertise in obesity and exercise physiology. The Physiology Core permits this Group to apply a number of advanced techniques to study and characterize individuals with diabetes and insulin resistance. The goal of the Health Services Research (HSR) Group is to improve the delivery of health care to persons with diabetes. The HSR Group has developed cooperative studies with the other three DRTC's which are also Diabetes Prevention Program (DPP) sites to take advantages of the DPP population. Within the HSR Group, the Model Diabetes Unit, the Education Design and Evaluation Core (EDEC) and the Outreach Core propose innovate projects to improve the ability of practitioners to deliver comprehensive diabetes care. These investigators depend on the Biostatistics, Immunologic Services and Physiology Cores. These and numerous institutional resources enhance the DRTC's ability to conduct research, to disseminate its results, and to improve the diagnosis and treatment of persons with diabetes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Comprehensive Center (P60)
Project #
5P60DK020542-23
Application #
6124756
Study Section
Special Emphasis Panel (ZDK1-GRB-C (O2))
Program Officer
Abraham, Kristin M
Project Start
1977-09-01
Project End
2002-11-30
Budget Start
1999-12-01
Budget End
2000-11-30
Support Year
23
Fiscal Year
2000
Total Cost
$1,605,353
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Hannon, Tamara S; Kirkman, M S; Patel, Yash R et al. (2014) Profound defects in ?-cell function in screen-detected type 2 diabetes are not improved with glucose-lowering treatment in the Early Diabetes Intervention Program (EDIP). Diabetes Metab Res Rev 30:767-76
Patel, Y R; Kirkman, M S; Considine, R V et al. (2013) Effect of acarbose to delay progression of carotid intima-media thickness in early diabetes. Diabetes Metab Res Rev 29:582-91
Kirkman, M Sue; Shankar, R Ravi; Shankar, Sudha et al. (2006) Treating postprandial hyperglycemia does not appear to delay progression of early type 2 diabetes: the Early Diabetes Intervention Program. Diabetes Care 29:2095-101
Wilson, Wayne A; Wang, Zhong; Roach, Peter J (2005) Regulation of yeast glycogen phosphorylase by the cyclin-dependent protein kinase Pho85p. Biochem Biophys Res Commun 329:161-7
Hermel, Evan; Hart, Andrew J; Gunduz, Irfan et al. (2004) Polymorphism and conservation of the genes encoding Qa1 molecules. Immunogenetics 56:639-49
Pederson, Bartholomew A; Wilson, Wayne A; Roach, Peter J (2004) Glycogen synthase sensitivity to glucose-6-P is important for controlling glycogen accumulation in Saccharomyces cerevisiae. J Biol Chem 279:13764-8
Wilson, Wayne A; Hughes, William E; Tomamichel, Wendy et al. (2004) Increased glycogen storage in yeast results in less branched glycogen. Biochem Biophys Res Commun 320:416-23
Duan, Chaojun; Li, Minghua; Rui, Liangyou (2004) SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin. J Biol Chem 279:43684-91
Shankar, Sudha S; Mirzamohammadi, Bahram; Walsh, James P et al. (2004) L-carnitine may attenuate free fatty acid-induced endothelial dysfunction. Ann N Y Acad Sci 1033:189-97
Thurmond, Debbie C; Gonelle-Gispert, Carmen; Furukawa, Megumi et al. (2003) Glucose-stimulated insulin secretion is coupled to the interaction of actin with the t-SNARE (target membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein) complex. Mol Endocrinol 17:732-42

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