Diabetes mellitus is one of the major health problems of the growing elderly population. The overall goal of the Diabetes Care for Order Adults Project (DCOAP) is to develop and test models of care for older adults with diabetes mellitus that can be translated into community practice. The initial phase of the DCOAP was carried out during the current funding cycle of the MDRTC as a randomized clinical trial comparing a program of insulin therapy combined with an intensive education and social support intervention with conventional physician directed patient care management. Preliminary results demonstrate substantial improvement of blood glucose control in the experimental intervention group with no detectable negative effects on patients' quality of life. The proposed activities for the next funding cycle of the MDRTC include follow-up and completion of the initial phase of the DCOAP and will emphasize two new specific objectives designed to aid in the translation of the initial phase of the DCOAP into clinical practice. One project is designed to determine if the successful results of the initial phase of the DCOAP can be replicated using a less resource intense care system that could be realistically adapted in community settings. A randomized clinical trial will be carried out comparing intensive team care management of elderly patients with diabetes, using the initial phase DCOAP model, with patient management by a diabetologist supported only by a standard hospital outpatient diabetes education program. If comparable outcomes are obtained, a key economic barrier to community translation of an intensive management program for older adults with diabetes mellitus will be eliminated. Because our experience with the initial phase of the DCOAP indicated that there is a substantial number of older adults with diabetes mellitus who are unwilling or unable to participate in an intensive treatment program emphasizing use of insulin, a second project is proposed to determine whether a management program which is based on patient-directed behavioral change and which minimizes use of insulin can improve blood sugar control in older adults with diabetes mellitus. To address this objective, a second randomized clinical trial will be carried out to compare outcomes of elderly diabetic patients participating in a management program based on patient-directed behavioral change with those of a control group of patients receiving standard care. Successful completion of the initial phase of the DCOAP plus the two new proposed translation projects will provide the basis for establishment of effective management strategies for older adults with diabetes mellitus that can be implemented in community practice.

Project Start
1996-12-01
Project End
1997-11-30
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
20
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Vollbrecht, Peter J; Nesbitt, Kathryn M; Mabrouk, Omar S et al. (2018) Cocaine and desipramine elicit distinct striatal noradrenergic and behavioral responses in selectively bred obesity-resistant and obesity-prone rats. Behav Brain Res 346:137-143
Jiang, Lin; Su, Haoran; Keogh, Julia M et al. (2018) Neural deletion of Sh2b1 results in brain growth retardation and reactive aggression. FASEB J 32:1830-1840
Yu, Sangho; Cheng, Helia; François, Marie et al. (2018) Preoptic leptin signaling modulates energy balance independent of body temperature regulation. Elife 7:
Rumora, Amy E; Lentz, Stephen I; Hinder, Lucy M et al. (2018) Dyslipidemia impairs mitochondrial trafficking and function in sensory neurons. FASEB J 32:195-207
Xiong, Yi; Torsoni, Adriana Souza; Wu, Feihua et al. (2018) Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases. Elife 7:
Tank, E M; Figueroa-Romero, C; Hinder, L M et al. (2018) Abnormal RNA stability in amyotrophic lateral sclerosis. Nat Commun 9:2845
Liu, Yan; Jiang, Lin; Sun, Chengxin et al. (2018) Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis. Nat Commun 9:2751
Sheng, Liang; Ye, Lan; Zhang, Dong et al. (2018) New Insights Into the Long Non-coding RNA SRA: Physiological Functions and Mechanisms of Action. Front Med (Lausanne) 5:244
Zhao, Xu-Yun; Xiong, Xuelian; Liu, Tongyu et al. (2018) Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis. Nat Commun 9:2986
Dreffs, Alyssa; Henderson, Desmond; Dmitriev, Andrey V et al. (2018) Retinal pH and Acid Regulation During Metabolic Acidosis. Curr Eye Res 43:902-912

Showing the most recent 10 out of 1081 publications