The Clinical Implementation Core (CIC) is the MDRTC name for the model demonstration unit, a required core in DRTCs. The CIC addresses issues in the first phase of the translation sequence, namely selection and adaptation of research findings for clinical care and the development and demonstration of model care programs. The principal model care development efforts of the CIC will occur in the context of the two projects for which this core will be responsible. These are D&E Project #1 -- Elderly Project, and D&E Project #2 -- Neuropathy Project. The conduct of these two projects will be CIC Aims #1 and #2, respectively.
The third Aim of the CIC will be to facilitate clinical research in diabetes. Two special activities will be included here: 1) the screening and clinical evaluation of patients who are candidates for experimental gene therapy maneuvers, and 2) recruitment of diabetic members and members of an unknown diabetic status of another large four-generation branch of the MODY RW pedigree to expand the registry of family members available for study of molecular genetic, hormonal and metabolic aspects of MODY.
The fourth Aim of the CIC addresses development of professional and patient education programs in diabetes and the demonstration of model diabetes care to health professional students. The staff of the CIC will be health professionals with special qualifications in diabetes who provide clinical expertise to the Biomedical Research and the D&E Division, its projects and cores.

Project Start
1999-03-15
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
22
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Vollbrecht, Peter J; Nesbitt, Kathryn M; Mabrouk, Omar S et al. (2018) Cocaine and desipramine elicit distinct striatal noradrenergic and behavioral responses in selectively bred obesity-resistant and obesity-prone rats. Behav Brain Res 346:137-143
Jiang, Lin; Su, Haoran; Keogh, Julia M et al. (2018) Neural deletion of Sh2b1 results in brain growth retardation and reactive aggression. FASEB J 32:1830-1840
Yu, Sangho; Cheng, Helia; François, Marie et al. (2018) Preoptic leptin signaling modulates energy balance independent of body temperature regulation. Elife 7:
Rumora, Amy E; Lentz, Stephen I; Hinder, Lucy M et al. (2018) Dyslipidemia impairs mitochondrial trafficking and function in sensory neurons. FASEB J 32:195-207
Xiong, Yi; Torsoni, Adriana Souza; Wu, Feihua et al. (2018) Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases. Elife 7:
Tank, E M; Figueroa-Romero, C; Hinder, L M et al. (2018) Abnormal RNA stability in amyotrophic lateral sclerosis. Nat Commun 9:2845
Liu, Yan; Jiang, Lin; Sun, Chengxin et al. (2018) Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis. Nat Commun 9:2751
Sheng, Liang; Ye, Lan; Zhang, Dong et al. (2018) New Insights Into the Long Non-coding RNA SRA: Physiological Functions and Mechanisms of Action. Front Med (Lausanne) 5:244
Zhao, Xu-Yun; Xiong, Xuelian; Liu, Tongyu et al. (2018) Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis. Nat Commun 9:2986
Dreffs, Alyssa; Henderson, Desmond; Dmitriev, Andrey V et al. (2018) Retinal pH and Acid Regulation During Metabolic Acidosis. Curr Eye Res 43:902-912

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