Abstract

This renewal application seeks continued support of a Molecular Biology Core Facility within the Washington University Diabetes Research and Training Center. This Core, established in 1987, offers support to established, NIH funded, investigators performing research in diabetes and related disorders. The Core is located within the Protein Chemistry Laboratory, a state of the art laboratory that provides state of the art services to the School of Medicine.
The specific aims of this Core are: 1. To quickly and efficiently provide high quality peptides, oligonucleotides, microsequencing analysis, amino acid compositional analysis, and HPLC separations. 2. To provide expertise, advice, and assistance in planning experimentation, interpreting results and, solving problems. 3. To provide research training to faculty and trainees.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Comprehensive Center (P60)
Project #
5P60DK020579-25
Application #
6564173
Study Section
Project Start
2001-12-01
Project End
2002-11-30
Budget Start
Budget End
Support Year
25
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Howard, Nicole C; Marin, Nancy D; Ahmed, Mushtaq et al. (2018) Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes. Nat Microbiol 3:1099-1108
Mukherjee, Sumit; Xu, Wei; Hsu, Fong-Fu et al. (2018) Sterol methyltransferase is required for optimal mitochondrial function and virulence in Leishmania major. Mol Microbiol :
Musselman, Laura Palanker; Fink, Jill L; Maier, Ezekiel J et al. (2018) Seven-Up Is a Novel Regulator of Insulin Signaling. Genetics 208:1643-1656
Henson, William R; Hsu, Fong-Fu; Dantas, Gautam et al. (2018) Lipid metabolism of phenol-tolerant Rhodococcus opacus strains for lignin bioconversion. Biotechnol Biofuels 11:339
Zayed, Mohamed A; Hsu, Fong-Fu; Patterson, Bruce W et al. (2018) Diabetes adversely affects phospholipid profiles in human carotid artery endarterectomy plaques. J Lipid Res 59:730-738
Xu, Wei; Mukherjee, Sumit; Ning, Yu et al. (2018) Cyclopropane fatty acid synthesis affects cell shape and acid resistance in Leishmania mexicana. Int J Parasitol 48:245-256
Chondronikola, Maria; Magkos, Faidon; Yoshino, Jun et al. (2018) Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial. Obesity (Silver Spring) 26:683-688
Rajagopal, Rithwick; Zhang, Sheng; Wei, Xiaochao et al. (2018) Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision. JCI Insight 3:
van Vliet, Stephan; Smith, Gordon I; Porter, Lane et al. (2018) The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle-aged women is not caused by leucine alone. J Physiol 596:4681-4692
Smith, Gordon I; Commean, Paul K; Reeds, Dominic N et al. (2018) Effect of Protein Supplementation During Diet-Induced Weight Loss on Muscle Mass and Strength: A Randomized Controlled Study. Obesity (Silver Spring) 26:854-861

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