The Diabetes Research and Training Center (DRTC) at Vanderbilt is one of a network of Core Centers established by the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) to conduct research and training in diabetes mellitus and related endocrine and metabolic disorders consistent with the National Diabetes Mellitus Research and Education Act, the report of the National Commission on Diabetes, and the Administrative Guidelines for DRTCs, as promulgated by the NIDDK. The Vanderbilt DRTC is a multi-disciplinary program with 81 participating faculty members distributed among 14 departments in 2 schools and 3 colleges of the University. The Biomedical Research Component consists of a research base of 64 investigators in the following interest areas: In vivo metabolism, Signal transduction, Etiology and complications, Gene regulation, Beta cell function, Demonstration and education. These investigators are supported by a Surgical and Analytical Services Core that is comprised of Hormone Assay, Amino Acid Assay and Animal Services subcores, and by the Cell and Molecular Biology Services Core that consists of DNA Chemistry, Media/Reagents, Cell Imaging and Transgenic Mouse/ES Cell subcores. A Pilot and Feasibility Studies Program helps new investigators initiate their research programs. The Demonstration/Education Component includes a Model Demonstration Unit that serves as the training laboratory for students in the health professions and it maintains a cohort of patients with diabetes who serve as volunteers for approved clinical research programs. The MDU also provides professional, technical and administrative support for Center investigators who conduct research in the General Clinical Research Center. This component also includes the Education/Evaluation Core that initiates and supports education research and instructional development activities. The Center coordinates three NIH-sponsored training programs that provide education and laboratory training in diabetes/endocrinology to medical students and graduate students and postdoctoral training for MDs and PhDs. An enrichment program provides continuing education through a Diabetes Research Day, a seminar series and annual symposia. The Administrative Component provides both scientific and administrative leadership for the total program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Comprehensive Center (P60)
Project #
5P60DK020593-21
Application #
2838042
Study Section
Special Emphasis Panel (SRC (01))
Program Officer
Abraham, Kristin M
Project Start
1996-02-13
Project End
2001-11-30
Budget Start
1999-03-15
Budget End
1999-11-30
Support Year
21
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Physiology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Wilson, Christopher S; Chhabra, Preeti; Marshall, Andrew F et al. (2018) Healthy Donor Polyclonal IgMs Diminish B-Lymphocyte Autoreactivity, Enhance Regulatory T-Cell Generation, and Reverse Type 1 Diabetes in NOD Mice. Diabetes 67:2349-2360
Hughey, Curtis C; Trefts, Elijah; Bracy, Deanna P et al. (2018) Glycine N-methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates. J Biol Chem 293:11944-11954
Yao, Lina; Seaton, Sarah Craven; Ndousse-Fetter, Sula et al. (2018) A selective gut bacterial bile salt hydrolase alters host metabolism. Elife 7:
Mani, Bharath K; Castorena, Carlos M; Osborne-Lawrence, Sherri et al. (2018) Ghrelin mediates exercise endurance and the feeding response post-exercise. Mol Metab 9:114-130
Bolus, W Reid; Peterson, Kristin R; Hubler, Merla J et al. (2018) Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments. Mol Metab 8:86-95
West, Kathryn L; Kelm, Nathaniel D; Carson, Robert P et al. (2018) Myelin volume fraction imaging with MRI. Neuroimage 182:511-521
Barke, Theresa L; Goldstein, Jeffery A; Sundermann, Alexandra C et al. (2018) Gestational diabetes mellitus is associated with increased CD163 expression and iron storage in the placenta. Am J Reprod Immunol 80:e13020
Rohrbough, Jeffrey; Nguyen, Hong-Ngan; Lamb, Fred S (2018) Modulation of ClC-3 gating and proton/anion exchange by internal and external protons and the anion selectivity filter. J Physiol 596:4091-4119
Schlegel, Cameron; Lapierre, Lynne A; Weis, Victoria G et al. (2018) Reversible deficits in apical transporter trafficking associated with deficiency in diacylglycerol acyltransferase. Traffic 19:879-892
Moore, Mary Courtney; Smith, Marta S; Farmer, Ben et al. (2018) Morning Hyperinsulinemia Primes the Liver for Glucose Uptake and Glycogen Storage Later in the Day. Diabetes 67:1237-1245

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