Abstract

The BCSCC continues committed to achieve its goals: To provide accurate hemoglobin phenotype testing of the population at risk for the hemoglobin S gene, in particular in the childbearing ages; to provide education and non-directive counseling to individuals and couples identified with hemoglobin traits; to increase the knowledge and awareness of sickle cell trait and sickle cell disease of health care providers and the general public; to provide comprehensive care and to promote a better quality of life for patients with sickle cell disease; through research projects to increase knowledge of sickle hemoglobin and cell disease and translate this into improve methods of detection of traits and treatment of patients with sickle cell disease; through collaboration among the comprehensive centers to maximize and enhance the productivity and effectiveness in achieving the centers' goals; and through the administrative core to coordinate the activities of the five BCSCC core components allowing for continuing exchanges of information between the research and service projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Comprehensive Center (P60)
Project #
3P60HL015157-31S1
Application #
6668102
Study Section
Special Emphasis Panel (ZHL1 (S1))
Program Officer
Evans, Gregory
Project Start
1977-04-10
Project End
2003-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
31
Fiscal Year
2002
Total Cost
$50,000
Indirect Cost

  Institution

Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Loscalzo, Joseph (2012) Irreproducible experimental results: causes, (mis)interpretations, and consequences. Circulation 125:1211-4
Steinberg, Martin H; Sebastiani, Paola (2012) Genetic modifiers of sickle cell disease. Am J Hematol 87:795-803
Vandorpe, David H; Xu, Chang; Shmukler, Boris E et al. (2010) Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes. PLoS One 5:e8732
Jahangir, Eiman; Vita, Joseph A; Handy, Diane et al. (2009) The effect of L-arginine and creatine on vascular function and homocysteine metabolism. Vasc Med 14:239-48
Casula, Sabina; Zolotarev, Alexander S; Stuart-Tilley, Alan K et al. (2009) Chemical crosslinking studies with the mouse Kcc1 K-Cl cotransporter. Blood Cells Mol Dis 42:233-40
Steinberg, Martin H; Voskaridou, Ersi; Kutlar, Abdullah et al. (2003) Concordant fetal hemoglobin response to hydroxyurea in siblings with sickle cell disease. Am J Hematol 72:121-6
Ware, Russell E; Eggleston, Barry; Redding-Lallinger, Rupa et al. (2002) Predictors of fetal hemoglobin response in children with sickle cell anemia receiving hydroxyurea therapy. Blood 99:10-4
Mirchev, R; Golan, D E (2001) Single-particle tracking and laser optical tweezers studies of the dynamics of individual protein molecules in membranes of intact human and mouse red cells. Blood Cells Mol Dis 27:143-7
Jiang, L; Jha, V; Dhanabal, M et al. (2001) Intracellular Ca(2+) signaling in endothelial cells by the angiogenesis inhibitors endostatin and angiostatin. Am J Physiol Cell Physiol 280:C1140-50
Shmukler, B E; Brugnara, C; Alper, S L (2000) Structure and genetic polymorphism of the mouse KCC1 gene. Biochim Biophys Acta 1492:353-61

Showing the most recent 10 out of 39 publications