The sickle cell program at St. Luke's-Roosevelt Hospital Center has been in existence for almost 25 years. The Program offers comprehensive medical care, i.e. total preventative and maintenance services, as well as diagnosis and management of acute chronic manifestations/complications of the disease and, when needed, referral for other medical problems as they arise. Nursing services, genetic counseling, social case work and counseling services are integral parts of the program. Support services are offered via group and individual approaches. All the diagnostic and therapeutic services available in a tertiary care facility are available to the patient. We plan to continue all of these efforts. For the next five years our specific objectives are to: I. Ensure that all patients have the availability of an appropriate medical 'home' by working with the state of New York, individual patients, and HMOs and other managed care organizations to guarantee experienced medical care for sickle cell patients. II. Expand our educational programs, via the media, and personal contact, with major emphasis on the Latino community, and managed care organizations, particularly those which will be accepting Medicaid patients. III. Establish and/or expand existing patient support groups. Program outreach to managed care organizations so that they recognize the importance of providing consultation services around those psychosocial issues which frequently and particularly concern sickle cell patients. IV. Concentrate initially on the following three new collaborative proposals: the pain program at Harlem Hospital, the Butyrate proposal at Mt. Sinai, and the HMO proposal at the University of North Carolina. In addition we will, of course continue with all current collaborative efforts.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Comprehensive Center (P60)
Project #
5P60HL028381-20
Application #
6584645
Study Section
Project Start
2002-04-01
Project End
2003-03-31
Budget Start
Budget End
Support Year
20
Fiscal Year
2002
Total Cost
$198,780
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Prohovnik, Isak; Hurlet-Jensen, Anne; Adams, Robert et al. (2009) Hemodynamic etiology of elevated flow velocity and stroke in sickle-cell disease. J Cereb Blood Flow Metab 29:803-10
Manwani, Deepa; Galdass, Mariann; Bieker, James J (2007) Altered regulation of beta-like globin genes by a redesigned erythroid transcription factor. Exp Hematol 35:39-47
Weinberg, Rona S; Ji, Xinjun; Sutton, Millicent et al. (2005) Butyrate increases the efficiency of translation of gamma-globin mRNA. Blood 105:1807-9
Rubin, Camelia Iancu; French, Deborah L; Atweh, George F (2003) Stathmin expression and megakaryocyte differentiation: a potential role in polyploidy. Exp Hematol 31:389-97
Day, Nancy S; Tadin, Marija; Christiano, Angela M et al. (2002) Rapid prenatal diagnosis of sickle cell diseases using oligonucleotide ligation assay coupled with laser-induced capillary fluorescence detection. Prenat Diagn 22:686-91
Turhan, Aslihan; Weiss, Linnea A; Mohandas, Narla et al. (2002) Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm. Proc Natl Acad Sci U S A 99:3047-51
Iancu, C; Mistry, S J; Arkin, S et al. (2001) Effects of stathmin inhibition on the mitotic spindle. J Cell Sci 114:909-16
Frenette, P S; Weiss, L (2000) Sulfated glycans induce rapid hematopoietic progenitor cell mobilization: evidence for selectin-dependent and independent mechanisms. Blood 96:2460-8
Pearson, M J; Lipowsky, H H (2000) Influence of erythrocyte aggregation on leukocyte margination in postcapillary venules of rat mesentery. Am J Physiol Heart Circ Physiol 279:H1460-71
O'Neill, D W; Schoetz, S S; Lopez, R A et al. (2000) An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells. Mol Cell Biol 20:7572-82

Showing the most recent 10 out of 114 publications