The Division of Clinical Research is designed to provide a mechanism to conduct the research projects within this application and to provide health care services to patients and families. Personnel of the Division of Clinical Research will be responsible for the recruitment and retention of patients for research, the collection of needed data and samples, and will participate in data analysis and the preparation of results for dissemination. Clinical Research Core staff also will support the Center's educational efforts and assist the Division of Policy and Ethics in formulating issues. Participating personnel from the Division include physicians, physician extenders, social workers, and data managers/patient care coordinators. The efforts of the Clinical Research Division core will be needed by all other Divisions within the Center for the Center to be successful in its research efforts. The Clinical Research Core has been successful in these efforts to date. Members of the Clinical Staff had made significant contributions to multiple projects from each of the Center's Divisions as illustrated by their authorship on many of the Center's publications. In addition, the Clinical Research core staff was instrumental in the development and implementation of the center wide data base that is being used in Center publications. This database will continue to be used by Investigators from all the Center's Divisions. In addition, the Clinical Research Division core will continue to provide quality care to patients and their families and see that the patients are informed as to the results of the research. It is the quality of the care and the support from the providers of the Clinical Research core that fosters participation of patients and families in the Center's research programs. The excellent record of patient participation in research projects is a tribute to this support.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Comprehensive Center (P60)
Project #
5P60HL028391-14
Application #
5213395
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
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Ware, Russell E; Eggleston, Barry; Redding-Lallinger, Rupa et al. (2002) Predictors of fetal hemoglobin response in children with sickle cell anemia receiving hydroxyurea therapy. Blood 99:10-4
Thompson Jr, Robert J; Gustafson, Kathryn E; Bonner, Melanie J et al. (2002) Neurocognitive development of young children with sickle cell disease through three years of age. J Pediatr Psychol 27:235-44
Slaughter, T F; Sreeram, G; Sharma, A D et al. (2001) Reversible shear-mediated platelet dysfunction during cardiac surgery as assessed by the PFA-100 platelet function analyzer. Blood Coagul Fibrinolysis 12:85-93
Lai, T S; Hausladen, A; Slaughter, T F et al. (2001) Calcium regulates S-nitrosylation, denitrosylation, and activity of tissue transglutaminase. Biochemistry 40:4904-10
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Lai, T S; Slaughter, T F; Peoples, K A et al. (1999) Site-directed mutagenesis of the calcium-binding site of blood coagulation factor XIIIa. J Biol Chem 274:24953-8
Lai, T S; Slaughter, T F; Peoples, K A et al. (1998) Regulation of human tissue transglutaminase function by magnesium-nucleotide complexes. Identification of distinct binding sites for Mg-GTP and Mg-ATP. J Biol Chem 273:1776-81

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