Abstract

The Sickle Cell Disease Association, Gulf Coast Alabama purposes to implement four long-term objectives which will result in a greater continuity of health care supportive services for clients with sickle cell disease in the gulf coast region. They are: OBJECTIVE 1 To create and implement an educational model that will facilitate an increased quality of life for clients with sickle cell disease through a provision of educational intervention seminars - Preventive Care Program (PCP) and to continue to enhance and expand the education, screening, counseling and supportive services through systematic program evaluations. OBJECTIVE 2 To identify and enroll adult clients in the Career Assistance Program so as to provide client services which will enhance employment training opportunities for persons with sickle cell disease and to develop and maintain an effective employer network, to develop and implement a youth component to the Career Assistance Program, and to expand and enhance the adult education referral system. OBJECTIVE 3 To develop and implement a statewide statistical support unit for data collection and analysis of information for community based programs in the state of Alabama. OBJECTIVE 4 To develop and implement a model training program for comprehensive care providers in urban and rural areas using the tracking procedures developed by the University of South Alabama Comprehensive Sickle Cell Center and the Community Based Sickle Cell Program in Mobile.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Comprehensive Center (P60)
Project #
5P60HL038639-08
Application #
3736630
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of South Alabama
Department
Type
DUNS #
City
Mobile
State
AL
Country
United States
Zip Code
36688

  Publications

Pace, B S; Qian, X; Ofori-Acquah, S F (2004) Selective inhibition of beta-globin RNA transcripts by antisense RNA molecules. Cell Mol Biol (Noisy-le-grand) 50:43-51
Haynes Jr, Johnson; Baliga, B Surendra; Obiako, Boniface et al. (2004) Zileuton induces hemoglobin F synthesis in erythroid progenitors: role of the L-arginine-nitric oxide signaling pathway. Blood 103:3945-50
Haynes Jr, Johnson; Obiako, Boniface (2002) Activated polymorphonuclear cells increase sickle red blood cell retention in lung: role of phospholipids. Am J Physiol Heart Circ Physiol 282:H122-30
Foley, Heather A; Ofori-Acquah, Solomon F; Yoshimura, Akihiko et al. (2002) Stat3 beta inhibits gamma-globin gene expression in erythroid cells. J Biol Chem 277:16211-9
Abraham, Ann; Bencsath, F Aladar; Shartava, Archil et al. (2002) Preparation of irreversibly sickled cell beta-actin from normal red blood cell beta-actin. Biochemistry 41:292-6
Kakhniashvili, D G; Goodman, S R (2001) Isolation of spectrin subunits by reverse-phase high-performance liquid chromatography. Protein Expr Purif 23:249-51
Sangerman, J; Kakhniashvili, D; Brown, A et al. (2001) Spectrin ubiquitination and oxidative stress: potential roles in blood and neurological disorders. Cell Mol Biol Lett 6:607-36
Yang, Y M; Pace, B (2001) Pharmacologic induction of fetal hemoglobin synthesis: cellular and molecular mechanisms. Pediatr Pathol Mol Med 20:87-106
Cepeda, M L; Allen, F H; Cepeda, N J et al. (2000) Physical growth, sexual maturation, body image and sickle cell disease. J Natl Med Assoc 92:4-Oct
Xu, L; Ferry, A E; Monteiro, C et al. (2000) Beta globin gene inhibition by antisense RNA transcripts. Gene Ther 7:438-44

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