This proposal requests funding to follow-up young men at high risk for the future development of alcoholism and control subjects who have been tested in our lab since 1978. Original Stage I evaluations of these 205 drinking but not alcoholic sons of alcoholic fathers (the family history positive or FHP men) and their 205 family history negative (FHN) controls was carried out at age 18 to 25 with the proposed follow-up to be completed when men are between age 30 and 35 (an average age of approximately 33 years). Our primary goal is to determine the combination of background data, family history of alcoholism, and measures of response to ethanol that best predict the Stage II follow-up status on drinking patterns, alcohol-related problems, and the development of alcohol abuse or alcohol dependence. The proposed Stage II evaluations will include face-to-face structured follow-up interviews with subjects and at least one resource person, record searches, obtaining blood samples (for blood alcohol concentrations, state markers of heavy drinking, and drug levels), as well as a short battery of 3 cognitive tests and a personality measure, the TPQ. A 95% successful follow-up is projected because our laboratory has maintained contact with the majority of subjects over the years and gathered information at the time of Stage I evaluations to expedite follow-up in the remainder. Secondary levels of analysis will also explore potential Stage I and interval history predictors of drug use and related problems, major mental health problems, and levels of cognitive functioning.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
2R01AA005526-07
Application #
3108986
Study Section
Alcohol Psychosocial Research Review Committee (ALCP)
Project Start
1982-09-29
Project End
1994-02-28
Budget Start
1989-03-01
Budget End
1990-02-28
Support Year
7
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Schuckit, Marc A (2018) A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. Alcohol Clin Exp Res 42:822-835
Gonçalves, Priscila Dib; Schuckit, Marc A; Smith, Tom L (2017) Drinking Status Between Ages 50 and 55 for Men From the San Diego Prospective Study Who Developed DSM-IV Alcohol Abuse or Dependence in Prior Follow-Ups. J Stud Alcohol Drugs 78:512-520
Schuckit, Marc A; Smith, Tom L; Heron, Jon et al. (2015) Latent trajectory classes for alcohol-related blackouts from age 15 to 19 in ALSPAC. Alcohol Clin Exp Res 39:108-16
Schuckit, Marc A (2014) A brief history of research on the genetics of alcohol and other drug use disorders. J Stud Alcohol Drugs Suppl 75 Suppl 17:59-67
Schuckit, Marc A; Smith, Tom L; Kalmijn, Jelger A (2014) The patterns of drug and alcohol use and associated problems over 30 years in 397 men. Alcohol Clin Exp Res 38:227-34
Schuckit, Marc A; Smith, Tom L (2013) Stability of scores and correlations with drinking behaviors over 15 years for the Self-Report of the Effects of Alcohol Questionnaire. Drug Alcohol Depend 128:194-9
Trim, Ryan S; Schuckit, Marc A; Smith, Tom L (2013) Predictors of initial and sustained remission from alcohol use disorders: findings from the 30-year follow-up of the San Diego Prospective Study. Alcohol Clin Exp Res 37:1424-31
Schuckit, Marc A; Smith, Tom L; Kalmijn, Jelger (2013) Relationships among independent major depressions, alcohol use, and other substance use and related problems over 30 years in 397 families. J Stud Alcohol Drugs 74:271-9
Schuckit, Marc A; Smith, Tom L; Kalmijn, Jelger et al. (2012) Comparison across two generations of prospective models of how the low level of response to alcohol affects alcohol outcomes. J Stud Alcohol Drugs 73:195-204
Schuckit, Marc A; Smith, Tom L; Trim, Ryan S et al. (2012) Sex differences in how a low sensitivity to alcohol relates to later heavy drinking. Drug Alcohol Rev 31:871-80

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