Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA008117-07
Application #
2044293
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1989-12-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Ernest Gallo Clinic and Research Center
Department
Type
DUNS #
173995366
City
Emeryville
State
CA
Country
United States
Zip Code
94608
Newton, Philip M; Zeng, Lily; Wang, Victoria et al. (2008) A blocker of N- and T-type voltage-gated calcium channels attenuates ethanol-induced intoxication, place preference, self-administration, and reinstatement. J Neurosci 28:11712-9
Newton, P M; Messing, R O (2006) Intracellular signaling pathways that regulate behavioral responses to ethanol. Pharmacol Ther 109:227-37
Newton, Philip M; Tully, Keith; McMahon, Thomas et al. (2005) Chronic ethanol exposure induces an N-type calcium channel splice variant with altered channel kinetics. FEBS Lett 579:671-6
Song, M; Messing, R O (2005) Protein kinase C regulation of GABAA receptors. Cell Mol Life Sci 62:119-27
Olive, M Foster; McGeehan, Andrew J; Kinder, Jennifer R et al. (2005) The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism. Mol Pharmacol 67:349-55
Olive, M Foster; Messing, Robert O (2004) Protein kinase C isozymes and addiction. Mol Neurobiol 29:139-54
Newton, Philip M; Orr, Christine J; Wallace, Melisa J et al. (2004) Deletion of N-type calcium channels alters ethanol reward and reduces ethanol consumption in mice. J Neurosci 24:9862-9
Choi, Doo-Sup; Messing, Robert O (2003) Animal models in the study of protein kinase C isozymes. Methods Mol Biol 233:455-73
Choi, Doo-Sup; Wang, Dan; Dadgar, Jahan et al. (2002) Conditional rescue of protein kinase C epsilon regulates ethanol preference and hypnotic sensitivity in adult mice. J Neurosci 22:9905-11
Hodge, Clyde W; Raber, Jacob; McMahon, Thomas et al. (2002) Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cepsilon. J Clin Invest 110:1003-10

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