This is a second resubmission of a competing renewal application, following three years of initial support. The applicant has determined that hippocampal LTP is ethanol sensitive. NMDA receptors seem to play a clear role in this sensitivity. However, inhibition of LTP by 100 mM ethanol exceeds that produced by inhibition of NMDA receptors by other pharmacological agents, leading to the hypothesis that an additional component of the inhibition may result from a ethanol's effects on GABAA receptors. This proposal further explores the actions of ethanol on NMDA receptor function, as well as probing the contribution and nature of GABAA receptors.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA009675-05
Application #
2855766
Study Section
Special Emphasis Panel (ZRG4-ALTX-3 (01))
Project Start
1993-09-30
Project End
2002-12-31
Budget Start
1999-01-01
Budget End
1999-12-31
Support Year
5
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Pharmacology
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
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