Abstract

Those of our investigations which involve controlled dietary restriction have now arrived at the stage where we are able to obtain a striking prolongation of the lifespan of an already long-lived strain of mouse. This prolongation is accompanied by a relative preservation into advanced age of immune response capacity. In our recentest work we find that immune rejuvenation and probably lifespan extension can be achieved by gradual dietary restriction beginning at mid-adulthood. This is unlike most or all prior work, which has only been done with restriction at time of weaning. In the future we shall be emphasizing mid-life restriction and it's effect upon immune, lifespan, and disease parameters. Effects of dietary restriction upon psychological tests, and chromatin will also be assessed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG000424-26
Application #
3114064
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1978-06-01
Project End
1992-04-30
Budget Start
1988-05-01
Budget End
1989-04-30
Support Year
26
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Aid, Saba; Bosetti, Francesca (2007) Gene expression of cyclooxygenase-1 and Ca(2+)-independent phospholipase A(2) is altered in rat hippocampus during normal aging. Brain Res Bull 73:108-13
Weerasinghe, Gayani R; Coon, Steven L; Bhattacharjee, Abesh Kumar et al. (2006) Regional protein levels of cytosolic phospholipase A2 and cyclooxygenase-2 in Rhesus monkey brain as a function of age. Brain Res Bull 69:614-21
Walford, R L; Bechtel, R; MacCallum, T et al. (1996) ""Biospheric medicine"" as viewed from the two-year first closure of Biosphere 2. Aviat Space Environ Med 67:609-17
Harris, S B; Gunion, M W; Rosenthal, M J et al. (1994) Serum glucose, glucose tolerance, corticosterone and free fatty acids during aging in energy restricted mice. Mech Ageing Dev 73:209-21
Effros, R B; Boucher, N; Porter, V et al. (1994) Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence. Exp Gerontol 29:601-9
Walford, R L; Harris, S B; Gunion, M W (1992) The calorically restricted low-fat nutrient-dense diet in Biosphere 2 significantly lowers blood glucose, total leukocyte count, cholesterol, and blood pressure in humans. Proc Natl Acad Sci U S A 89:11533-7
May, P C; Telford, N; Salo, D et al. (1992) Failure of dietary restriction to retard age-related neurochemical changes in mice. Neurobiol Aging 13:787-91
Effros, R B; Svoboda, K; Walford, R L (1991) Influence of age and caloric restriction on macrophage IL-6 and TNF production. Lymphokine Cytokine Res 10:347-51
Fu, C S; Harris, S B; Wilhelmi, P et al. (1991) Lack of effect of age and dietary restriction on DNA single-stranded breaks in brain, liver, and kidney of (C3H x C57BL/10)F1 mice. J Gerontol 46:B78-80
Spindler, S R; Grizzle, J M; Walford, R L et al. (1991) Aging and restriction of dietary calories increases insulin receptor mRNA, and aging increases glucocorticoid receptor mRNA in the liver of female C3B10RF1 mice. J Gerontol 46:B233-7

Showing the most recent 10 out of 22 publications