Abstract

Prospective studies carried out by the Precursors Study suggest the existence of psychological factors which precede the clinical appearance of premature disease or death by many years. We obtained an extensive, unique data base (psychological, psychosocial, physiological, medical and familial) on a cohort of 1,337 medical students and have followed them prospectively for 18 to 32 years. Now for the most part between the ages of 41 and 60, 68 of them have died, and more than 200 are living with serious disorders, including hypertension, coronary heart disease, cancer and mental illness. It is our aim: a. to study the enlarging disorder group in detail in an attempt to substantiate the youthful psychological characteristics we have already found in this cohort which appear to be potential predictors of several disease states; b. to search prospectively for new potential predictors within the psychological and behavorial data; c. to determine whether special clusters of predictive variables appear to be associated with particular types of disease; and d. to bring together the substance of the Precursors Study's findings to date.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG001760-11
Application #
3114262
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1979-08-01
Project End
1993-02-28
Budget Start
1991-03-05
Budget End
1992-02-29
Support Year
11
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Armstrong, Nicole M; Meoni, Lucy A; Carlson, Michelle C et al. (2017) Cardiovascular risk factors and risk of incident depression throughout adulthood among men: The Johns Hopkins Precursors Study. J Affect Disord 214:60-66
Shihab, Hasan M; Meoni, Lucy A; Chu, Audrey Y et al. (2012) Body mass index and risk of incident hypertension over the life course: the Johns Hopkins Precursors Study. Circulation 126:2983-9
Gross, Alden L; Rebok, George W; Ford, Daniel E et al. (2011) Alcohol consumption and domain-specific cognitive function in older adults: longitudinal data from the Johns Hopkins Precursors Study. J Gerontol B Psychol Sci Soc Sci 66:39-47
Engelman, Michal; Agree, Emily M; Meoni, Lucy A et al. (2010) Propositional density and cognitive function in later life: findings from the Precursors Study. J Gerontol B Psychol Sci Soc Sci 65:706-11
Chu, Audrey Y; Meoni, Lucy A; Wang, Nae Yuh et al. (2010) Reliability of alcohol recall after 15 years and 23 years of follow-up in the Johns Hopkins Precursors Study. J Stud Alcohol Drugs 71:143-9
Wittink, Marsha N; Morales, Knashawn H; Meoni, Lucy A et al. (2008) Stability of preferences for end-of-life treatment after 3 years of follow-up: the Johns Hopkins Precursors Study. Arch Intern Med 168:2125-30
Wang, Nae-Yuh; Young, J Hunter; Meoni, Lucy A et al. (2008) Blood pressure change and risk of hypertension associated with parental hypertension: the Johns Hopkins Precursors Study. Arch Intern Med 168:643-8
Li, Erning; Wang, Naisyin; Wang, Nae-Yuh (2007) Joint models for a primary endpoint and multiple longitudinal covariate processes. Biometrics 63:1068-78
Kittleson, Michelle M; Meoni, Lucy A; Wang, Nae-Yuh et al. (2006) Association of childhood socioeconomic status with subsequent coronary heart disease in physicians. Arch Intern Med 166:2356-61
Barone, Bethany B; Clark, Jeanne M; Wang, Nae-Yuh et al. (2006) Lifetime weight patterns in male physicians: the effects of cohort and selective survival. Obesity (Silver Spring) 14:902-8

Showing the most recent 10 out of 48 publications