Abstract

This application represents a request to extend for an additional five years, an existing study of the natural history of Alzheimer's disease. The objectives of the study are to further describe the borders between normal aging and Alzheimer's disease, identify stage-specific prognoses of mild, moderate and severe dementias, examine factors which identify malignant versus benign course of AD, and provide markers for differing prognostic subgroups. Investigators will conduct follow-up studies of four cohorts each involving a combination of normal older persons, Alzheimer's disease patients, and patients with Alzheimer's disease and other causes of cognitive impairment. Collectively, these cohorts include over 1300 persons. The comprehensive evaluations include behavioral, mental status, neuropsychologic, neurologic, neuroimaging, electrophysiologic, and postmortem studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
2R01AG003051-14
Application #
2402656
Study Section
Human Development and Aging Subcommittee 3 (HUD)
Project Start
1982-03-01
Project End
2002-06-30
Budget Start
1997-08-01
Budget End
1998-06-30
Support Year
14
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016

  Publications

Reisberg, Barry; Shao, Yongzhao; Golomb, James et al. (2017) Comprehensive, Individualized, Person-Centered Management of Community-Residing Persons with Moderate-to-Severe Alzheimer Disease: A Randomized Controlled Trial. Dement Geriatr Cogn Disord 43:100-117
Molinuevo, José L; Rabin, Laura A; Amariglio, Rebecca et al. (2017) Implementation of subjective cognitive decline criteria in research studies. Alzheimers Dement 13:296-311
Rabin, Laura A; Smart, Colette M; Crane, Paul K et al. (2015) Subjective Cognitive Decline in Older Adults: An Overview of Self-Report Measures Used Across 19 International Research Studies. J Alzheimers Dis 48 Suppl 1:S63-86
Auer, Stefanie R; Span, Edith; Reisberg, Barry (2015) Dementia service centres in Austria: A comprehensive support and early detection model for persons with dementia and their caregivers - theoretical foundations and model description. Dementia (London) 14:513-27
Guerrero-Berroa, Elizabeth; Kluger, Alan; Schmeidler, James et al. (2014) Neuropsychological and neuropsychiatric prediction of global cognitive status among older Spanish-speaking Hispanics and English-speaking whites. J Geriatr Psychiatry Neurol 27:266-75
Reisberg, Barry; Monteiro, Isabel; Torossian, Carol et al. (2014) The BEHAVE-AD assessment system: a perspective, a commentary on new findings, and a historical review. Dement Geriatr Cogn Disord 38:89-146
Shankle, William R; Pooley, James P; Steyvers, Mark et al. (2013) Relating memory to functional performance in normal aging to dementia using hierarchical Bayesian cognitive processing models. Alzheimer Dis Assoc Disord 27:16-22
Wegiel, Jerzy; Kaczmarski, Wojciech; Barua, Madhabi et al. (2011) Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome. J Neuropathol Exp Neurol 70:36-50
Sabbagh, M N; Cooper, K; DeLange, J et al. (2010) Functional, global and cognitive decline correlates to accumulation of Alzheimer's pathology in MCI and AD. Curr Alzheimer Res 7:280-6
Reisberg, Barry; Shulman, Melanie B; Torossian, Carol et al. (2010) Outcome over seven years of healthy adults with and without subjective cognitive impairment. Alzheimers Dement 6:11-24

Showing the most recent 10 out of 102 publications