Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG003763-10
Application #
2048778
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1983-08-01
Project End
1996-12-31
Budget Start
1996-02-10
Budget End
1996-12-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Ohio State University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210
Ginn-Pease, M E; Whisler, R L (2001) Alterations in the expression of interleukin-2R subunits by activated T cells from elderly humans are uncoupled from aberrancies in G1/S progression. J Interferon Cytokine Res 21:515-21
Karanfilov, C I; Liu, B; Fox, C C et al. (1999) Age-related defects in Th1 and Th2 cytokine production by human T cells can be dissociated from altered frequencies of CD45RA+ and CD45RO+ T cell subsets. Mech Ageing Dev 109:97-112
Whisler, R L; Chen, M; Liu, B et al. (1999) Age-related impairments in TCR/CD3 activation of ZAP-70 are associated with reduced tyrosine phosphorylations of zeta-chains and p59fyn/p56lck in human T cells. Mech Ageing Dev 111:49-66
Liu, B; Whisler, R L (1998) Transcriptional activation and redox regulation of the tumor necrosis factor-alpha promoter in human T cells: role of the CRE/kappa3 promoter region. J Interferon Cytokine Res 18:999-1007
Whisler, R L; Karanfilov, C I; Newhouse, Y G et al. (1998) Phosphorylation and coupling of zeta-chains to activated T-cell receptor (TCR)/CD3 complexes from peripheral blood T-cells of elderly humans. Mech Ageing Dev 105:115-35
Ginn-Pease, M E; Whisler, R L (1998) Redox signals and NF-kappaB activation in T cells. Free Radic Biol Med 25:346-61
Liu, B; Carle, K W; Whisler, R L (1997) Reductions in the activation of ERK and JNK are associated with decreased IL-2 production in T cells from elderly humans stimulated by the TCR/CD3 complex and costimulatory signals. Cell Immunol 182:79-88
Whisler, R L; Bagenstose, S E; Newhouse, Y G et al. (1997) Expression and catalytic activities of protein tyrosine kinases (PTKs) Fyn and Lck in peripheral blood T cells from elderly humans stimulated through the T cell receptor (TCR)/CD3 complex. Mech Ageing Dev 98:57-73
Whisler, R L; Chen, M; Beiqing, L et al. (1997) Impaired induction of c-fos/c-jun genes and of transcriptional regulatory proteins binding distinct c-fos/c-jun promoter elements in activated human T cells during aging. Cell Immunol 175:41-50
Whisler, R L; Beiqing, L; Chen, M (1996) Age-related decreases in IL-2 production by human T cells are associated with impaired activation of nuclear transcriptional factors AP-1 and NF-AT. Cell Immunol 169:185-95

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