Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
2R01AG005731-07A2
Application #
2049338
Study Section
Immunobiology Study Section (IMB)
Project Start
1986-08-01
Project End
2001-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
Fallah, Mosoka P; Chelvarajan, R Lakshman; Garvy, Beth A et al. (2011) Role of phosphoinositide 3-kinase-Akt signaling pathway in the age-related cytokine dysregulation in splenic macrophages stimulated via TLR-2 or TLR-4 receptors. Mech Ageing Dev 132:274-86
Dasu, Trivikram; Sindhava, Vishal; Clarke, Stephen H et al. (2009) CD19 signaling is impaired in murine peritoneal and splenic B-1 B lymphocytes. Mol Immunol 46:2655-65
Wu, Hsin-Jung; Bondada, Subbarao (2009) CD72, a coreceptor with both positive and negative effects on B lymphocyte development and function. J Clin Immunol 29:12-21
Dasu, Trivikram; Qualls, Joseph E; Tuna, Halide et al. (2008) CD5 plays an inhibitory role in the suppressive function of murine CD4(+) CD25(+) T(reg) cells. Immunol Lett 119:103-13
Gururajan, Murali; Simmons, Alan; Dasu, Trivikram et al. (2008) Early growth response genes regulate B cell development, proliferation, and immune response. J Immunol 181:4590-602
Garg, M; Kaplan, A M; Bondada, S (1994) Cellular basis of differential responsiveness of lymph nodes and spleen to 23-valent Pnu-Imune vaccine. J Immunol 152:1589-96
Muthukkumar, S; Udhayakumar, V; Bondada, S (1993) Elevation of cytosolic calcium is sufficient to induce growth inhibition in a B cell lymphoma. Eur J Immunol 23:2419-26
Baluyut, A R; Pollok, K E; Bondada, S (1993) Molecular events in B lymphocyte activation: consequences of signals transduced through MHC class II molecules. Cell Immunol 147:353-66
Garg, M; Bondada, S (1993) Reversal of age-associated decline in immune response to Pnu-imune vaccine by supplementation with the steroid hormone dehydroepiandrosterone. Infect Immun 61:2238-41
Muthusamy, N; Bondada, S (1993) Differential regulation of surface immunoglobulin and Lyb2 mediated B cell activation: II. cAMP dependent (prostaglandin E2) and independent (IFN-gamma) mechanisms of regulation of B lymphocyte activation. Int Immunol 5:949-56

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