Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG006656-10
Application #
2049587
Study Section
Neurology B Subcommittee 2 (NEUB)
Project Start
1986-12-01
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Holth, Jerrah K; Bomben, Valerie C; Reed, J Graham et al. (2013) Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy. J Neurosci 33:1651-9
Ertekin-Taner, N; Younkin, L H; Yager, D M et al. (2008) Plasma amyloid beta protein is elevated in late-onset Alzheimer disease families. Neurology 70:596-606
Graff-Radford, Neill R; Crook, Julia E; Lucas, John et al. (2007) Association of low plasma Abeta42/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease. Arch Neurol 64:354-62
Jankowsky, Joanna L; Younkin, Linda H; Gonzales, Victoria et al. (2007) Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice. J Biol Chem 282:22707-20
Jankowsky, Joanna L; Melnikova, Tatiana; Fadale, Daniel J et al. (2005) Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease. J Neurosci 25:5217-24
Ertekin-Taner, Nilufer; Ronald, James; Feuk, Lars et al. (2005) Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene. Hum Mol Genet 14:447-60
Ertekin-Taner, Nilufer; Allen, Mariet; Fadale, Daniel et al. (2004) Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease. Hum Mutat 23:334-42
Ertekin-Taner, Nilufer; Ronald, James; Asahara, Hideaki et al. (2003) Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Hum Mol Genet 12:3133-43
Wahrle, Suzanne; Das, Pritam; Nyborg, Andrew C et al. (2002) Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiol Dis 9:11-23
Das, P; Murphy, M P; Younkin, L H et al. (2001) Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition. Neurobiol Aging 22:721-7

Showing the most recent 10 out of 30 publications