The prevalence of dementia, its public health importance, and its effect on health care costs have now been documented in a variety of populations. Further elucidation of the incidence, risk factors, associated features, and distribution of the different dementing disorders requires longitudinal studies of well-characterized population samples. A major obstacle to conducting such studies is the absence of normative population data on cognitive functioning and change over time. The current proposal seeks to continue an ongoing prospective community study of cognitive impairment and dementia in the rural mid-Monongahela Valley region of Southwestern Pennsylvania, about 25 miles south of Pittsburgh. A cohort of non-institutionalized persons aged 65 and older, who met basic education and fluency criteria, was assembled as part of a survey to establish a population-based dementia registry starting in 1987. This cohort was made up of an age-stratified random sample of 1366 and a volunteer sample of 259 subjects. Since 1989, the survivors of the cohort have been followed with repeated cognitive screening at 18-24 month intervals, with the primary goals of identifying incident cases of dementia and risk factors for dementia, as well as normal and abnormal patterns of cognitive change over time. We propose to follow the cohort with identical methods over a further 5-year period, so as to accrue a greater number of incident cases and maximize the utility of existing baseline and followup data enabling us to identify predictors of cognitive decline and dementia. We will also accumulate a larger number of outcome events (institutionalization and death) so as to identify the predictors of these outcomes. Progress to date is reported, including data on comorbidity of dementia and on cognitive decline in the cohort over the first followup period. Additional objectives are to refine cognitive screening methodology, particularly for distinguishing normal from abnormal decline, and to explore the pharmacoepidemiology of cognitive impairment and dementia.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG007562-07
Application #
2049797
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1989-01-01
Project End
1997-07-31
Budget Start
1994-08-01
Budget End
1995-07-31
Support Year
7
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Karch, Celeste M; Ezerskiy, Lubov A; Bertelsen, Sarah et al. (2016) Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. PLoS One 11:e0148717
Mez, Jesse; Mukherjee, Shubhabrata; Thornton, Timothy et al. (2016) The executive prominent/memory prominent spectrum in Alzheimer's disease is highly heritable. Neurobiol Aging 41:115-121
Ridge, Perry G; Hoyt, Kaitlyn B; Boehme, Kevin et al. (2016) Assessment of the genetic variance of late-onset Alzheimer's disease. Neurobiol Aging 41:200.e13-200.e20
Ebbert, Mark T W; Boehme, Kevin L; Wadsworth, Mark E et al. (2016) Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk. Alzheimers Dement 12:121-129
Chaudhry, Mamoonah; Wang, Xingbin; Bamne, Mikhil N et al. (2015) Genetic variation in imprinted genes is associated with risk of late-onset Alzheimer's disease. J Alzheimers Dis 44:989-94
Ganguli, Mary; Lee, Ching-Wen; Snitz, Beth E et al. (2014) How well do MCI criteria predict progression to severe cognitive impairment and dementia? Alzheimer Dis Assoc Disord 28:113-21
Cruchaga, Carlos; Karch, Celeste M; Jin, Sheng Chih et al. (2014) Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature 505:550-554
Dodge, Hiroko H; Zhu, Jian; Lee, Ching-Wen et al. (2014) Cohort effects in age-associated cognitive trajectories. J Gerontol A Biol Sci Med Sci 69:687-94
Sachdev, Perminder S; Lipnicki, Darren M; Kochan, Nicole A et al. (2013) COSMIC (Cohort Studies of Memory in an International Consortium): an international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups. BMC Neurol 13:165
Karp, Jordan F; Lee, Ching-Wen; McGovern, Jonathan et al. (2013) Clinical and demographic covariates of chronic opioid and non-opioid analgesic use in rural-dwelling older adults: the MoVIES project. Int Psychogeriatr 25:1801-10

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