Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG007657-08
Application #
2049849
Study Section
Special Emphasis Panel (ZRG4-GRM (01))
Project Start
1988-08-01
Project End
1998-03-31
Budget Start
1996-05-24
Budget End
1997-03-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Southern Methodist University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75205
Sohal, Rajindar S; Forster, Michael J (2014) Caloric restriction and the aging process: a critique. Free Radic Biol Med 73:366-82
Klichko, Vladimir; Sohal, Barbara H; Radyuk, Svetlana N et al. (2014) Decrease in cytochrome c oxidase reserve capacity diminishes robustness of Drosophila melanogaster and shortens lifespan. Biochem J 459:127-35
Orr, William C; Radyuk, Svetlana N; Sohal, Rajindar S (2013) Involvement of redox state in the aging of Drosophila melanogaster. Antioxid Redox Signal 19:788-803
Sohal, Rajindar S; Orr, William C (2012) The redox stress hypothesis of aging. Free Radic Biol Med 52:539-555
Ren, Jian-Ching; Rebrin, Igor; Klichko, Vladimir et al. (2010) Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster. Biochem Biophys Res Commun 401:64-8
Mockett, Robin J; Sohal, Barbara H; Sohal, Rajindar S (2010) Expression of multiple copies of mitochondrially targeted catalase or genomic Mn superoxide dismutase transgenes does not extend the life span of Drosophila melanogaster. Free Radic Biol Med 49:2028-31
Radyuk, Svetlana N; Michalak, Katarzyna; Klichko, Vladimir I et al. (2009) Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity in Drosophila. Biochem J 419:437-45
Sohal, Rajindar S; Toroser, Dikran; Bregere, Catherine et al. (2008) Age-related decrease in expression of mitochondrial DNA encoded subunits of cytochrome c oxidase in Drosophila melanogaster. Mech Ageing Dev 129:558-61
Rebrin, Igor; Sohal, Rajindar S (2008) Pro-oxidant shift in glutathione redox state during aging. Adv Drug Deliv Rev 60:1545-52
Toroser, Dikran; Orr, William C; Sohal, Rajindar S (2007) Carbonylation of mitochondrial proteins in Drosophila melanogaster during aging. Biochem Biophys Res Commun 363:418-24

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