Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG007988-03S1
Application #
3119376
Study Section
Nutrition Study Section (NTN)
Project Start
1990-01-01
Project End
1994-12-31
Budget Start
1992-01-01
Budget End
1992-12-31
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Temple University
Department
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Boden, G (2003) Effects of free fatty acids (FFA) on glucose metabolism: significance for insulin resistance and type 2 diabetes. Exp Clin Endocrinol Diabetes 111:121-4
Boden, Guenther; Cheung, Peter; Stein, T Peter et al. (2002) FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis. Am J Physiol Endocrinol Metab 283:E12-9
Boden, Guenther (2002) Interaction between free fatty acids and glucose metabolism. Curr Opin Clin Nutr Metab Care 5:545-9
Boden, G; Shulman, G I (2002) Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest 32 Suppl 3:14-23
Itani, Samar I; Ruderman, Neil B; Schmieder, Frank et al. (2002) Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes 51:2005-11
Homko, C; Sivan, E; Chen, X et al. (2001) Insulin secretion during and after pregnancy in patients with gestational diabetes mellitus. J Clin Endocrinol Metab 86:568-73
Boden, G; Chen, X; Stein, T P (2001) Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus. Am J Physiol Endocrinol Metab 280:E23-30
Boden, G (2001) Pathogenesis of type 2 diabetes. Insulin resistance. Endocrinol Metab Clin North Am 30:801-15, v
Boden, G; Lebed, B; Schatz, M et al. (2001) Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes 50:1612-7
Boden, G; Chen, X; Capulong, E et al. (2001) Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes. Diabetes 50:810-6

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