The broad objective of the present proposal is to examine changes in memory functioning in later life. The research is rooted in our earlier work which suggests that changes in memory performance may depend substantially on individual differences in the decline of information processing and intellectual ability components underlying the complex tasks typically used to measure memory. From this perspective, age- related declines in memory cannot be expected for all older adults, but only for those individuals who have experienced sufficient decline in the components necessary for successful task performance. The study is also designed to examine the potential mediators of this differential decline of processes and abilities. First, the study will examine whether such decline may be related to physical health. Second, it will investigate whether the everyday environment of many older adults may lack sufficient cognitive demand to maintain optimal memory performance. Finally, the research is designed to explore whether lower feelings of self-efficacy in memory-demanding situations may contribute to performance declines. The research is based on an ongoing longitudinal study of older adults. Participants are tested at three-year intervals, with new samples of participants added at six-year intervals. The addition of new independent samples expands the design into a sequential data collection strategy. In 1986, 484 community-dwelling adults completed a battery of tasks designed to measure memory performance, information processing and intellectual abilities, self-reported physical health, cognitive demand level of everyday activities, beliefs and feelings about cognitive functioning, and aspects of personality. In 1989, 328 of these individuals returned to be retested. The present proposal is for the third follow-up of the original sample, as well as the selection of a new sample of 500 individuals to be tested for the first time. In sum, the proposed research is designed to examine: (a) the extent to which age-related changes in memory functioning result from a pattern of differential decline of component information processing and intellectual abilities, and (b) the extent to which patterns of cognitive change in adulthood are mediated by physical health, activity life style, and personal belief variables.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
2R01AG008235-03
Application #
3119771
Study Section
Human Development and Aging Subcommittee 3 (HUD)
Project Start
1989-08-01
Project End
1995-11-30
Budget Start
1993-03-19
Budget End
1993-11-30
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Victoria
Department
Type
DUNS #
209567957
City
Victoria
State
BC
Country
Canada
Zip Code
V8 5-C2
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Han, Wei; Sapkota, Shraddha; Camicioli, Richard et al. (2017) Profiling novel metabolic biomarkers for Parkinson's disease using in-depth metabolomic analysis. Mov Disord 32:1720-1728
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Sapkota, Shraddha; Bäckman, Lars; Dixon, Roger A (2017) Executive function performance and change in aging is predicted by apolipoprotein E, intensified by catechol-O-methyltransferase and brain-derived neurotrophic factor, and moderated by age and lifestyle. Neurobiol Aging 52:81-89
Brown, Cassandra L; Robitaille, Annie; Zelinski, Elizabeth M et al. (2016) Cognitive activity mediates the association between social activity and cognitive performance: A longitudinal study. Psychol Aging 31:831-846
DeCarlo, Correne A; MacDonald, Stuart W S; Vergote, David et al. (2016) Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study. J Gerontol B Psychol Sci Soc Sci 71:1004-1014
Sapkota, Shraddha; Wiebe, Sandra A; Small, Brent J et al. (2016) Apolipoprotein E and Clusterin can magnify effects of personality vulnerability on declarative memory performance in non-demented older adults. Int J Geriatr Psychiatry 31:502-9

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