Abstract

Studies have shown that there is a strong relationship between sleep disordered breathing (SDB) and dementia and patients with Alzheimer's Disease having a high rate of SDB. This application will examine whether treating SDB with nasal CPAP in patients with AD will result in improvement in cognitive functioning.
The specific aims are to assess whether patients with mild AD will tolerate CPAP and be compliant with the treatment; to examine the effect of CPAP treatment on SDB; to examine the effects of CPAP treatment on cognitive functioning in patients with mild AD and SDB; to examine whether improvement is greater after 6 weeks of CPAP treatment than after 3 weeks. Because caregivers are often disturbed by the patient's poor sleep, the effect of treatment on the caregiver will also be evaluated. The secondary aim is to evaluate whether caregivers feel that their own sleep improves as the patient's sleep improves. Patients will be randomized to a CPAP treatment group or sham CPAP group. After 3 weeks, the sham group will also be switched to CPAP. Measures of neuropsychological performance will be obtained at baseline and after 3 and 6 weeks of treatment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG008415-13
Application #
6627915
Study Section
Special Emphasis Panel (ZRG1-RPHB-2 (01))
Program Officer
Monjan, Andrew A
Project Start
1989-05-01
Project End
2006-01-31
Budget Start
2003-02-01
Budget End
2004-01-31
Support Year
13
Fiscal Year
2003
Total Cost
$267,268
Indirect Cost

  Institution

Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Harmell, Alexandrea L; Neikrug, Ariel B; Palmer, Barton W et al. (2016) Obstructive Sleep Apnea and Cognition in Parkinson's disease. Sleep Med 21:28-34
Ensrud, Kristine E; Parimi, Neeta; Fink, Howard A et al. (2014) Estimated GFR and risk of hip fracture in older men: comparison of associations using cystatin C and creatinine. Am J Kidney Dis 63:31-9
Maglione, Jeanne E; Ancoli-Israel, Sonia; Peters, Katherine W et al. (2014) Depressive symptoms and circadian activity rhythm disturbances in community-dwelling older women. Am J Geriatr Psychiatry 22:349-61
Spira, Adam P; Stone, Katie L; Rebok, George W et al. (2014) Sleep-disordered breathing and functional decline in older women. J Am Geriatr Soc 62:2040-6
Patterson, Ruth E; Emond, Jennifer A; Natarajan, Loki et al. (2014) Short sleep duration is associated with higher energy intake and expenditure among African-American and non-Hispanic white adults. J Nutr 144:461-6
Stone, Katie L; Blackwell, Terri L; Ancoli-Israel, Sonia et al. (2014) Sleep disturbances and risk of falls in older community-dwelling men: the outcomes of Sleep Disorders in Older Men (MrOS Sleep) Study. J Am Geriatr Soc 62:299-305
Mander, Bryce A; Rao, Vikram; Lu, Brandon et al. (2014) Impaired prefrontal sleep spindle regulation of hippocampal-dependent learning in older adults. Cereb Cortex 24:3301-9
Edwards, Kate M; Kamat, Rujvi; Tomfohr, Lianne M et al. (2014) Obstructive sleep apnea and neurocognitive performance: the role of cortisol. Sleep Med 15:27-32
von Känel, Roland; Mausbach, Brent T; Ancoli-Israel, Sonia et al. (2014) Positive affect and sleep in spousal Alzheimer caregivers: a longitudinal study. Behav Sleep Med 12:358-72
Cauley, Jane A; Blackwell, Terri L; Redline, Susan et al. (2014) Hypoxia during sleep and the risk of falls and fractures in older men: the Osteoporotic Fractures in Men Sleep Study. J Am Geriatr Soc 62:1853-9

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