Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG011658-04
Application #
2052878
Study Section
Biological and Clinical Aging Review Committee (BCA)
Project Start
1993-09-06
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Berkeley
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Kim, Sahn-Ho; Davalos, Albert R; Heo, Seok-Jin et al. (2008) Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes. J Cell Biol 181:447-60
Davalos, Albert R; Kaminker, Patrick; Hansen, Rhonda K et al. (2004) ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation. Cell Cycle 3:1579-86
Tan, Siyuan; Guschin, Dmitry; Davalos, Albert et al. (2003) Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity. Proc Natl Acad Sci U S A 100:11997-2002
Chen, Lishan; Huang, Shurong; Lee, Lin et al. (2003) WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair. Aging Cell 2:191-9
Davalos, Albert R; Campisi, Judith (2003) Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks. J Cell Biol 162:1197-209
Oshima, Junko; Huang, Shurong; Pae, Chong et al. (2002) Lack of WRN results in extensive deletion at nonhomologous joining ends. Cancer Res 62:547-51
Yannone, S M; Roy, S; Chan, D W et al. (2001) Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase. J Biol Chem 276:38242-8
Bischof, O; Galande, S; Farzaneh, F et al. (2001) Selective cleavage of BLM, the bloom syndrome protein, during apoptotic cell death. J Biol Chem 276:12068-75
Bischof, O; Kim, S H; Irving, J et al. (2001) Regulation and localization of the Bloom syndrome protein in response to DNA damage. J Cell Biol 153:367-80
Huang, S; Beresten, S; Li, B et al. (2000) Characterization of the human and mouse WRN 3'-->5' exonuclease. Nucleic Acids Res 28:2396-405

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