Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG012694-02S1
Application #
2327066
Study Section
Special Emphasis Panel (ZRG1-BPO (02))
Project Start
1995-09-30
Project End
2000-08-31
Budget Start
1996-09-20
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Snigdha, Shikha; Yassa, Michael A; deRivera, Christina et al. (2017) Pattern separation and goal-directed behavior in the aged canine. Learn Mem 24:123-131
Snigdha, Shikha; Prieto, G Aleph; Petrosyan, Arpine et al. (2016) H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus. J Neurosci 36:3611-22
Snigdha, Shikha; de Rivera, Christina; Milgram, Norton W et al. (2016) Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine. Neurobiol Aging 37:171-178
Snigdha, Shikha; Milgram, Norton W; Willis, Sherry L et al. (2013) A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap. Neurobiol Aging 34:1891-901
Snigdha, Shikha; Smith, Erica D; Prieto, G Aleph et al. (2012) Caspase-3 activation as a bifurcation point between plasticity and cell death. Neurosci Bull 28:14-24
Dowling, Amy L S; Head, Elizabeth (2012) Antioxidants in the canine model of human aging. Biochim Biophys Acta 1822:685-9
Fahnestock, Margaret; Marchese, Monica; Head, Elizabeth et al. (2012) BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog. Neurobiol Aging 33:546-54
Snigdha, Shikha; Christie, Lori-Ann; De Rivera, Christina et al. (2012) Age and distraction are determinants of performance on a novel visual search task in aged Beagle dogs. Age (Dordr) 34:67-73
Pop, Viorela; Head, Elizabeth; Berchtold, Nicole C et al. (2012) A? aggregation profiles and shifts in APP processing favor amyloidogenesis in canines. Neurobiol Aging 33:108-20
Snigdha, Shikha; Berchtold, Nicole; Astarita, Giuseppe et al. (2011) Dietary and behavioral interventions protect against age related activation of caspase cascades in the canine brain. PLoS One 6:e24652

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