Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG012721-01A3
Application #
2001596
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1996-09-30
Project End
2001-08-31
Budget Start
1996-09-30
Budget End
1997-08-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Pathology
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Park, Kevin H J; Lu, Ge; Fan, Jing et al. (2012) Decreasing Levels of the cdk5 Activators, p25 and p35, Reduces Excitotoxicity in Striatal Neurons. J Huntingtons Dis 1:89-96
Park, Kevin H J; Vincent, Inez (2008) Presymptomatic biochemical changes in hindlimb muscle of G93A human Cu/Zn superoxide dismutase 1 transgenic mouse model of amyotrophic lateral sclerosis. Biochim Biophys Acta 1782:462-8
Zhang, Min; Hallows, Janice L; Wang, Xuezhen et al. (2008) Mitogen-activated protein kinase activity may not be necessary for the neuropathology of Niemann-Pick type C mice. J Neurochem 107:814-22
Park, Kevin H J; Hallows, Janice L; Chakrabarty, Paramita et al. (2007) Conditional neuronal simian virus 40 T antigen expression induces Alzheimer-like tau and amyloid pathology in mice. J Neurosci 27:2969-78
Hallows, Janice L; Iosif, Robert E; Biasell, Rebecca D et al. (2006) p35/p25 is not essential for tau and cytoskeletal pathology or neuronal loss in Niemann-Pick type C disease. J Neurosci 26:2738-44
Rashidian, Juliet; Iyirhiaro, Grace; Aleyasin, Hossein et al. (2005) Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo. Proc Natl Acad Sci U S A 102:14080-5
Zhang, Min; Li, Jin; Chakrabarty, Paramita et al. (2004) Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice. Am J Pathol 165:843-53
Hallows, Janice L; Chen, Ken; DePinho, Ronald A et al. (2003) Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice. J Neurosci 23:10633-44
Lu, Kun Ping; Liou, Yih-Cherng; Vincent, Inez (2003) Proline-directed phosphorylation and isomerization in mitotic regulation and in Alzheimer's Disease. Bioessays 25:174-81
Vincent, Inez; Pae, Chong In; Hallows, Janice L (2003) The cell cycle and human neurodegenerative disease. Prog Cell Cycle Res 5:31-41

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