Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
7R01AG014913-02
Application #
6032267
Study Section
Special Emphasis Panel (ZRG4-GRM (06))
Project Start
1998-04-15
Project End
2003-03-31
Budget Start
1998-11-11
Budget End
1999-03-31
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Mcp Hahnemann University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19102
Jiang, Jiu; Fisher, Erin M; Murasko, Donna M (2013) Intrinsic defects in CD8 T cells with aging contribute to impaired primary antiviral responses. Exp Gerontol 48:579-86
Williams-Bey, Yolanda; Jiang, Jiu; Murasko, Donna M (2011) Expansion of regulatory T cells in aged mice following influenza infection. Mech Ageing Dev 132:163-70
Jiang, Jiu; Fisher, Erin M; Murasko, Donna M (2011) CD8 T cell responses to influenza virus infection in aged mice. Ageing Res Rev 10:422-7
Jiang, Jiu; Fisher, Erin; Bennett, Andrew J et al. (2010) Enhancement of virus-specific expansion of transgenic CD8 T cells in aged mice by dendritic cells. Mech Ageing Dev 131:580-3
Jiang, Jiu; Bennett, Andrew J; Fisher, Erin et al. (2009) Limited expansion of virus-specific CD8 T cells in the aged environment. Mech Ageing Dev 130:713-21
Jiang, Jiu; Gross, Diara; Elbaum, Philip et al. (2007) Aging affects initiation and continuation of T cell proliferation. Mech Ageing Dev 128:332-9
Murasko, Donna M; Jiang, Jiu (2005) Response of aged mice to primary virus infections. Immunol Rev 205:285-96
Jiang, Jiu; Gross, Diara; Nogusa, Shoko et al. (2005) Depletion of T cells by type I interferon: differences between young and aged mice. J Immunol 175:1820-6
Jiang, Jiu; Anaraki, Farvardin; Blank, Kenneth J et al. (2003) Cuttine edge: T cells from aged mice are resistant to depletion early during virus infection. J Immunol 171:3353-7
Elrefaei, Mohamed; Blank, Kenneth J; Murasko, Donna M (2002) Decreased IL-2, IFN-gamma, and IL-10 production by aged mice during the acute phase of E55+ retrovirus infection. Virology 299:8-19

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