This is a resubmission of a competitive renewal R01 application to continue the research project """"""""Demographic Analysis on Determinants of Healthy Longevity in China"""""""" (PI: Yi Zeng). We are requesting 5-year research support from 7/1/2010 to 6/30/2015, with substantial matching funds from Chinese resources. The goal of this proposed continuing R01 is to search for a better understanding of the effects of social, behavioral, and genetic factors and their interactions on healthy longevity. More specifically, we plan to achieve our goal through the following research activities. (1) Collect follow-up data on mortality and changes in health status in 2011 and 2014 for those 14,000 interviewees who contributed DNA samples for the first time in 2008. (2) Identify the healthy longevity related genes by genome-wide screening and genotyping with the two-stage study design of population association analysis as well as the convergent statistical analyses. (3) Innovatively apply advanced demographic/statistical methods to analyze the CLHLS multi-wave longitudinal survey data and genotype data produced by this project in an integrated way to estimate the impacts of environmental and genetic risk factors on health and longevity at old ages. In addition to studying the general associations between environmental and genetic factors, we plan to pay particular attention to analyze the effects of environment-gene interactions on healthy longevity. (4) Develop the genotypic and phenotypic database (including health conditions, disability status, behavior, life style, diet, psychological characteristics, survival and death, etc.). We will make this database of the world's largest sample of centenarians, nonagenarians, younger elderly, and middle-aged controls user-friendly and widely available to all interested scholars, while eliminating all information which may be potentially used to identify the individual participants.

Public Health Relevance

This is the resubmission of the competitive renewal R01 application to continue the research project """"""""Demographic Analysis on Determinants of Healthy Longevity in China"""""""" (PI: Yi Zeng), with substantial matching funds from Chinese resources. The goal of this proposed continuing R01 is to search for a better understanding of the effects of social, behavioral and genetic factors and their interactions on healthy longevity. We emphasize studying factors affecting health at old ages in the context of expanding lifespan, based on well-conducted interdisciplinary research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG023627-06A2S1
Application #
8262761
Study Section
Social Sciences and Population Studies Study Section (SSPS)
Program Officer
Patmios, Georgeanne E
Project Start
2004-09-01
Project End
2015-08-31
Budget Start
2011-05-15
Budget End
2011-08-31
Support Year
6
Fiscal Year
2011
Total Cost
$108,714
Indirect Cost
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Liu, Zu-Yun; Wei, Yin-Zhi; Wei, Li-Qing et al. (2018) Frailty transitions and types of death in Chinese older adults: a population-based cohort study. Clin Interv Aging 13:947-956
Tian, Maoyi; Yin, Xuejun; Dunzhu, Danzeng et al. (2018) A qualitative evaluation of a simplified cardiovascular management program in Tibet, China. Global Health 14:24
Zeng, Yi; Nie, Chao; Min, Junxia et al. (2018) Sex Differences in Genetic Associations With Longevity. JAMA Netw Open 1:
Zeng, Yi; Feng, Qiushi; Gu, Danan et al. (2017) Demographics, phenotypic health characteristics and genetic analysis of centenarians in China. Mech Ageing Dev 165:86-97
Zeng, Yi; Feng, Qiushi; Hesketh, Therese et al. (2017) Survival, disabilities in activities of daily living, and physical and cognitive functioning among the oldest-old in China: a cohort study. Lancet 389:1619-1629
Gao, Min; Li, Yanyu; Zhang, Shengfa et al. (2017) Does an Empty Nest Affect Elders' Health? Empirical Evidence from China. Int J Environ Res Public Health 14:
Lei, Peng; Feng, Zhixin; Wu, Zhuochun (2016) The availability and affordability of long-term care for disabled older people in China: The issues related to inequalities in social security benefits. Arch Gerontol Geriatr 67:21-7
Gu, Danan; Zhu, Haiyan; Brown, Tyson et al. (2016) Tourism Experiences and Self-Rated Health Among Older Adults in China. J Aging Health 28:675-703
Lv, Y-B; Yin, Z X; Chei, C-L et al. (2016) Serum Cholesterol Levels within the High Normal Range Are Associated with Better Cognitive Performance among Chinese Elderly. J Nutr Health Aging 20:280-7
Zeng, Yi; Brasher, Melanie Sereny; Gu, Danan et al. (2016) Older Parents Benefit More in Health Outcome From Daughters' Than Sons' Emotional Care in China. J Aging Health 28:1426-1447

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