Insomnia is a prominent complaint in late-life. However, little scientific effort has been directed toward identifying the biological mechanisms that are related to abnormal sleep or to evaluating the efficacy of behavioral treatments for insomnia in older adults. Basic observations demonstrate that proinflammatory cytokines play a key role in the regulation of sleep. Our translation of cytokine-sleep mechanisms into the clinic show that cytokines are reciprocally linked with abnormal sleep. The proposed research builds upon these findings and extends a program of study that has examined the efficacy of behavioral interventions on health outcomes in the elderly. Preliminary studies show found that Tai Chi Chih (TCC), a slow moving meditation, contributes to improvements in subjective sleep quality, sleep amounts and sleep efficiency, alterations in sympathetic activity, decreases in proinflammatory cytokines, and improvements in health functioning in community-dwelling older adults. Additionally, cognitive behavior therapy (CBT) confers benefits on sleep outcomes. In this randomized, controlled trial, 150 older adults will be randomly assigned to CBT, TCC, or sleep hygiene/ education control (EC) over 16 weeks and followed for one year.
The aims of this project are to: 1) evaluate the effects of CBT vs TCC vs. EC on objective and subjective measures of sleep and on fatigue, mood, and health functioning in older adults with insomnia;2) determine the effects of CBT vs.TCC vs. EC on measures of proinflammatory cytokine activity and sympathovagal balance, and whether these two biological mechanisms are related to changes of disordered sleep over the course of the treatment trial;and 3) evaluate whether circulating levels of proinflammatory cytokines are associated with measures of sleep continuity in older adults with insomnia over the treatment trial. This study will advance psychobiological models of disordered sleep and the potential benefits of two readily exportable behavioral interventions for promoting improvements in sleep outcomes in the elderly.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG026364-05
Application #
7672241
Study Section
Psychosocial Risk and Disease Prevention Study Section (PRDP)
Program Officer
Mackiewicz, Miroslaw
Project Start
2005-09-01
Project End
2011-02-28
Budget Start
2009-09-01
Budget End
2011-02-28
Support Year
5
Fiscal Year
2009
Total Cost
$486,720
Indirect Cost
Name
University of California Los Angeles
Department
Psychiatry
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Kruse, Jennifer L; Congdon, Eliza; Olmstead, Richard et al. (2018) Inflammation and Improvement of Depression Following Electroconvulsive Therapy in Treatment-Resistant Depression. J Clin Psychiatry 79:
Eisenberger, Naomi I; Moieni, Mona; Inagaki, Tristen K et al. (2017) In Sickness and in Health: The Co-Regulation of Inflammation and Social Behavior. Neuropsychopharmacology 42:242-253
Bjurström, Martin F; Olmstead, Richard; Irwin, Michael R (2017) Reciprocal Relationship Between Sleep Macrostructure and Evening and Morning Cellular Inflammation in Rheumatoid Arthritis. Psychosom Med 79:24-33
Carroll, Judith E; Irwin, Michael R; Levine, Morgan et al. (2017) Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women's Health Initiative Study. Biol Psychiatry 81:136-144
Irwin, Michael R; Opp, Mark R (2017) Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity. Neuropsychopharmacology 42:129-155
Irwin, Michael R; Olmstead, Richard; Carrillo, Carmen et al. (2017) Tai Chi Chih Compared With Cognitive Behavioral Therapy for the Treatment of Insomnia in Survivors of Breast Cancer: A Randomized, Partially Blinded, Noninferiority Trial. J Clin Oncol 35:2656-2665
Cho, Hyong Jin; Savitz, Jonathan; Dantzer, Robert et al. (2017) Sleep disturbance and kynurenine metabolism in depression. J Psychosom Res 99:1-7
Irwin, Michael R; Eisenberger, Naomi I (2017) Context-Dependent Effects of Inflammation: Reduced Reward Responding is Not an Invariant Outcome of Sickness. Neuropsychopharmacology 42:785-786
Chiang, Jessica J; Tsai, Kim M; Park, Heejung et al. (2016) Daily family stress and HPA axis functioning during adolescence: The moderating role of sleep. Psychoneuroendocrinology 71:43-53
Youngstedt, Shawn D; Goff, Eric E; Reynolds, Alexandria M et al. (2016) Has adult sleep duration declined over the last 50+ years? Sleep Med Rev 28:69-85

Showing the most recent 10 out of 113 publications